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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neuroanatomía ganglios basales > DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista >

A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys
Authors: Rico, A.J. (Alberto J.)
Barroso-Chinea, P. (P.)
Conte-Perales, L. (L.)
Roda, E. (Elvira)
Gomez-Bautista, V. (V.)
Gendive, M. (M.)
Obeso, J.A. (José A.)
Lanciego, J.L. (José Luis)
Keywords: Basal ganglia
MPTP
Hyperdirect pathway
Retrograde tracing
Parkinson's disease
Issue Date: 2010
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/S0969996110001555
ISSN: 1095-953X
Citation: Rico AJ, Barroso-Chinea P, Conte-Perales L, Roda E, Gomez-Bautista V, Gendive M, et al. A direct projection from the subthalamic nucleus to the ventral thalamus in monkeys. Neurobiol Dis 2010 Sep;39(3):381-392.
Abstract
The current basal ganglia model considers the internal division of the globus pallidus and the substantia nigra pars reticulata as the sole sources of basal ganglia output to the thalamus. However, following the delivery of retrograde tracers into the ventral anterior/ventral lateral thalamic nuclei, a moderate number of labeled neurons were found within the subthalamic nucleus (STN) in control cases, MPTP-treated monkeys and animals with levodopa-induced dyskinesias. Furthermore, dual tracing experiments showed that subthalamo-thalamic and subthalamo-pallidal projections arise from different subpopulations of STN efferent neurons. Moreover, upregulated expression of the mRNA coding the vesicular glutamate transporter 2 (vGlut2) was found in retrogradely-labeled STN neurons in MPTP-treated monkeys. By contrast, there is a reduction in vGlut2 mRNA expression in subthalamo-thalamic neurons in dyskinetic monkeys. In conclusion, our findings support the presence of a direct projection from the STN to the ventral thalamus that appears to be functionally modulated by dopaminergic activity.
Permanent link: http://hdl.handle.net/10171/20119
Appears in Collections:DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista

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