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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neuroanatomía ganglios basales > DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista >

Changes to interneuron-driven striatal microcircuits in a rat model of Parkinson's disease
Authors: Salin, P. (Pascal)
Lopez, I.P. (Iciar P.)
Kachidian, P. (P.)
Barroso-Chinea, P. (P.)
Rico, A.J. (Alberto J.)
Gomez-Bautista, V. (V.)
Coulon, P. (Patrice)
Kerkerian-Le-Goff, L. (Lydia)
Lanciego, J. (J.L.)
Keywords: Rabies virus
ChAT
Dopamine
Caudate–putame
Basal ganglia
Issue Date: 2009
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/S0969996109000667
ISSN: 1095-953X
Citation: Salin P, Lopez IP, Kachidian P, Barroso-Chinea P, Rico AJ, Gomez-Bautista V, et al. Changes to interneuron-driven striatal microcircuits in a rat model of Parkinson's disease. Neurobiol Dis 2009 Jun;34(3):545-552.
Abstract
Striatal interneurons play key roles in basal ganglia function and related disorders by modulating the activity of striatal projection neurons. Here we have injected rabies virus (RV) into either the rat substantia nigra pars reticulata or the globus pallidus and took advantage of the trans-synaptic spread of RV to unequivocally identify the interneurons connected to striatonigral- or striatopallidal-projecting neurons, respectively. Large numbers of RV-infected parvalbumin (PV+/RV+) and cholinergic (ChAT+/RV+) interneurons were detected in control conditions, and they showed marked changes following intranigral 6-hydroxydopamine injection. The number of ChAT+/RV+ interneurons innervating striatopallidal neurons increased concomitant with a reduction in the number of PV+/RV+ interneurons, while the two interneuron populations connected to striatonigral neurons were clearly reduced. These data provide the first evidence of synaptic reorganization between striatal interneurons and projection neurons, notably a switch of cholinergic innervation onto striatopallidal neurons, which could contribute to imbalanced striatal outflow in parkinsonian state.
Permanent link: http://hdl.handle.net/10171/20121
Appears in Collections:DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista

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