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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neuroanatomía ganglios basales > DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista >

Glutamatergic pallidothalamic projections and their implications in the pathophysiology of Parkinson's disease
Authors: Barroso-Chinea, P. (P.)
Rico, A.J. (Alberto J.)
Perez-Manso, M. (Mónica)
Roda, E. (Elvira)
Lopez, I.P. (Iciar P.)
Luis-Ravelo, D. (Diego)
Lanciego, J. (J.L.)
Keywords: Entopeduncular nucleus
Substantia nigra
Basal ganglia
GABA
Glutamate
VGLUT2
Issue Date: 2008
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/S096999610800123X
ISSN: 1095-953X
Citation: Barroso-Chinea P, Rico AJ, Perez-Manso M, Roda E, Lopez IP, Luis-Ravelo D, et al. Glutamatergic pallidothalamic projections and their implications in the pathophysiology of Parkinson's disease. Neurobiol Dis 2008 Sep;31(3):422-432.
Abstract
GABAergic projections emitted from the entopeduncular nucleus (ENT) and the substantia nigra pars reticulata (SNr) innervate different thalamic nuclei and they are known to be hyperactive after dopaminergic depletion. Here we show that isoform 2 of the vesicular glutamate transporter (VGLUT2) is expressed by neurons in the ENT nucleus but not in the SNr. Indeed, dual in situ hybridization demonstrated that the ENT nucleus contains two different subpopulations of projection neurons, one single-expressing GAD65/67 mRNAs and another one that co-expresses either of the GAD isoforms together with VGLUT2 mRNA. Unilateral dopaminergic depletion induced marked changes in pallidothalamic-projecting neuron gene expression, resulting in increased expression of GAD65/67 mRNAs together with a clear down-regulation of VGLUT2 mRNA expression. Our results indicate that the increased thalamic inhibition typical of dopamine depletion might be explained by a synergistic effect of increased GABA outflow coupled to decreased glutamate levels, both neurotransmitters coming from ENT neurons.
Permanent link: http://hdl.handle.net/10171/20122
Appears in Collections:DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista

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