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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neuroanatomía ganglios basales > DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista >

Long-term neuroprotection and neurorestoration by glial cell-derived neurotrophic factor microspheres for the treatment of parkinson's disease
Authors: Garbayo, E. (Elisa)
Ansorena, E. (Eduardo)
Lanciego, J.L. (J.L.)
Blanco-Prieto, M.J. (María José)
Aymerich, M.S. (María S.)
Keywords: Parkinson’s disease
Glial cell-derived neurotrophic factor
Microspheres
Neurodegeneration
6-hydroxydopamine
Tyrosine hydroxylase
Issue Date: 2011
Publisher: Wiley Blackwell
Publisher version: http://dx.doi.org/10.1002/mds.23793
ISSN: 1531-8257
Citation: Garbayo E, Ansorena E, Luis Lanciego J, Jose Blanco-Prieto M, Aymerich MS. Long-term neuroprotection and neurorestoration by glial cell-derived neurotrophic factor microspheres for the treatment of parkinson's disease. Mov Disord 2011 Aug 15;26(10):1943-1947.
Abstract
BACKGROUND: Glial cell-derived neurotrophic factor is a survival factor for dopaminergic neurons and a promising candidate for the treatment of Parkinson's disease. However, the delivery issue of the protein to the brain still remains unsolved. Our aim was to investigate the effect of long-term delivery of encapsulated glial cell-derived neurotrophic factor within microspheres. METHODS: A single dose of microspheres containing 2.5 μg of glial cell-derived neurotrophic factor was implanted intrastriatally in animals 2 weeks after a 6-hydroxydopamine lesion. RESULTS: The amphetamine test showed a complete behavioral recovery after 16 weeks of treatment, which was maintained until the end of the study (week 30). This effect was accompanied by an increase in dopaminergic striatal terminals and neuroprotection of dopaminergic neurons. CONCLUSIONS: The main achievement was the long-term neurorestoration in parkinsonian animals induced by encapsulated glial cell-derived neurotrophic factor, suggesting that microspheres may be considered as a means to deliver glial cell-derived neurotrophic factor for Parkinson's disease treatment. © 2011 Movement Disorder Society.
Permanent link: http://hdl.handle.net/10171/20124
Appears in Collections:DA - Farmacia - Tecnología Farmacéutica - Artículos de revista
DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista

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