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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neuroanatomía ganglios basales > DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista >

Lesion of the centromedian thalamic nucleus in MPTP-treated monkeys
Authors: Lanciego, J.L. (José Luis)
Rodriguez-Oroz, M.C. (María Cruz)
Blesa, F.J. (F.J.)
Alvarez-Erviti, L. (Lydia)
Guridi, J. (Jorge)
Barroso-Chinea, P. (P.)
Smith, Y. (Yoland)
Obeso, J.A. (José A.)
Keywords: intralaminar thalamic nuclei
MPTP monkey model
Kainic acid lesion
Parkinson’s disease
Issue Date: 2008
Publisher: Wiley Blackwell
Publisher version: http://bit.ly/uF6SPz
ISSN: 1531-8257
Citation: Lanciego JL, Rodriguez-Oroz MC, Blesa FJ, Alvarez-Erviti L, Guridi J, Barroso-Chinea P, et al. Lesion of the centromedian thalamic nucleus in MPTP-treated monkeys. Mov Disord 2008 Apr 15;23(5):708-715.
Abstract
The caudal intralaminar nuclei are a major source of glutamatergic afferents to the basal ganglia. Experiments in the 6-hydroxydopamine rat model have shown that the parafascicular nucleus is overactive and its lesion alleviates basal ganglia neurochemical abnormalities associated with dopamine depletion. Accordingly, removal of this excitatory innervation of the basal ganglia could have a beneficial value in the parkinsonian state. To test this hypothesis, unilateral kainate-induced chemical ablation of the centromedian thalamic nucleus (CM) has been performed in MPTP-treated monkeys. Successful lesions restricted to the CM boundaries (n = 2) without spreading over other neighboring thalamic nuclei showed an initial, short-lasting, and mild change in the parkinsonian motor scale but no effect against levodopa-induced dyskinesias. The lack of significant and persistent motor improvement leads us to conclude that unilateral selective lesion of the CM alone cannot be considered as a suitable surgical approach for the treatment of PD or levodopa-induced dyskinesias. The role of the caudal intralaminar nuclei in the pathophysiology of movement disorders of basal ganglia origin remains to be clarified.
Permanent link: http://hdl.handle.net/10171/20125
Appears in Collections:DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista

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