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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neuroanatomía ganglios basales > DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista >

Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis
Authors: Lanciego, J.L. (José Luis)
Barroso-Chinea, P. (P.)
Rico, A.J. (Alberto J.)
Conte-Perales, L. (L.)
Callen, L. (L.)
Roda, E. (Elvira)
Gomez-Bautista, V. (V.)
Lopez, I.P. (Iciar P.)
Lluis, C. (Carmen)
Labandeira-Garcia, J.L. (José L.)
Franco, R. (Rafael)
Keywords: Basal ganglia
Brain
Endocannabinoids
In situ hybridization
Levodopa
Issue Date: 2010
Publisher: Sage Publications
Publisher version: http://jop.sagepub.com/content/25/1/97
ISSN: 1461-7285
Citation: Lanciego JL, Barroso-Chinea P, Rico AJ, Conte-Perales L, Callen L, Roda E, et al. Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis. J Psychopharmacol 2011 Jan;25(1):97-104.
Abstract
The putative presence of the cannabinoid receptor type 2 (CB(2)-R) in the central nervous system is still a matter of debate. Although first described in peripheral and immune tissues, evidence suggesting the existence of CB(2)-Rs in glial cells and even neurons has been made available more recently. By taking advantage of newly designed CB(2)-R mRNA riboprobes, we have demonstrated by in situ hybridization and PCR the existence of CB2-R transcripts in a variety of brain areas of the primate Macaca fascicularis, including the cerebral cortex and the hippocampus, as well as in the external and internal divisions of the globus pallidus, both pallidal segments showing the highest abundance of CB(2)-R transcripts. In this regard, the presence of the messenger coding CB(2)-Rs within the pallidal complex highlights their consideration as potential targets for the treatment of movement disorders of basal ganglia origin.
Permanent link: http://hdl.handle.net/10171/20126
Appears in Collections:DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Neurociencias - Neuroanatomía ganglios basales - Artículos de Revista

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