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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Oncología > Biomarcadores > DA - CIMA - Oncología - Biomarcadores - Artículos de Revista >

Adrenomedullin and proadrenomedullin N-terminal 20 peptide in the normal prostate and in prostate carcinoma
Authors: Calvo, A. (Alfonso)
Abasolo, I. (Ibane)
Jimenez, N. (Nuria)
Wang, Z. (Zhou)
Montuenga, L.M. (Luis M.)
Keywords: Prostate
Neuroendocrine
Amidation
Prostate cancer
Androgens
Issue Date: 2002
Publisher: Wiley Blackwell
Publisher version: http://onlinelibrary.wiley.com/doi/10.1002/jemt.10056/abstract
ISSN: 1097-0029
Citation: Calvo A, Abasolo I, Jimenez N, Wang Z, Montuenga L. Adrenomedullin and proadrenomedullin N-terminal 20 peptide in the normal prostate and in prostate carcinoma. Microsc Res Tech 2002 Apr 15;57(2):98-104.
Abstract
There is increasing evidence for the important role played by regulatory peptides in the physiology of the normal and neoplastic prostate. Adrenomedullin (AM) and pro-adrenomedullin N-terminal 20 peptide (PAMP) are recently discovered regulatory peptides widely expressed in the normal prostate and in prostate carcinoma. AM is produced in secretory, stroma, and endothelial cells and in neurons of the prostate ganglia. PAMP is only produced by neuroendocrine cells. The expression of AM mRNA is regulated by androgens in the rat prostate. The number of neuroendocrine cells expressing PAMP is increased in prostate carcinoma after androgen deprivation, which shows that this peptide could regulate androgen-independent prostate tumor growth. However, the roles of AM and PAMP in the normal prostate and in prostate carcinoma are yet to be elucidated.
Permanent link: http://hdl.handle.net/10171/20186
Appears in Collections:DA - CIMA - Oncología - Nuevas dianas terapéuticas - Artículos de revista
DA - Ciencias - HAP - Artículos de revista
DA - CIMA - Oncología - Biomarcadores - Artículos de Revista

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