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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neurofarmacología y conducta > DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista >

Effect of selective cholinergic denervation on the serotonergic system: implications for learning and memory
Authors: Garcia-Alloza, M. (Mónica)
Zaldua, N. (Natalia)
Diez-Ariza, M. (Mónica)
Marcos, B. (Beatriz)
Lasheras, B. (Berta)
Gil-Bea, F. (Francisco J.)
Ramirez, M.J. (María Javier)
Keywords: Cholinergic lesion
192-IgG-saporin
5-HT1A receptors
5-HT1B receptors
5-hydroxytriptophan
Morris water maze
Passive avoidance
Issue Date: 2006
Publisher: Lippincott Williams and Wilkins
Publisher version: http://bit.ly/uEah9l
ISSN: 1554-6578
Citation: Garcia-Alloza M, Zaldua N, Diez-Ariza M, Marcos B, Lasheras B, Javier Gil-Bea F, et al. Effect of selective cholinergic denervation on the serotonergic system: implications for learning and memory. J Neuropathol Exp Neurol 2006 Nov;65(11):1074-1081.
Abstract
The cholinergic system has been widely implicated in cognitive processes and cholinergic loss is a classical hallmark in Alzheimer disease. Increasing evidence supports a role of the serotonergic system in cognition, possibly through a modulation of cholinergic activity. We compared selective cholinergic denervation by administration of the immunotoxin 192 IgG-saporin in the nucleus basalis of Meynert (NBM) with intracerebroventricular (ICV) lesions of the basal forebrain in male rats 7 days after lesioning. NBM lesions induced significant changes in cholinergic markers in the frontal cortex, whereas ICV lesions produced significant decreases in cholinergic markers both in the frontal cortex and hippocampus. Only ICV lesions lead to memory impairments in passive avoidance and Morris water maze tasks. Both models lead to reductions of serotonin levels in the frontal cortex. Similar changes in 5-hydroxytriptophan levels were observed, suggesting a downregulation of the rate-limiting enzyme for the synthesis of serotonin along with the cholinergic deficit. Neither 5-HT1A nor 5-HT1B receptors seem to mediate this process. These data imply that the serotonergic system in the frontal cortex can compensate for diminished cholinergic function and support the investigation of the serotonergic system as a therapeutic target to treat Alzheimer disease.
Permanent link: http://hdl.handle.net/10171/20204
Appears in Collections:DA - Farmacia - Farmacología - Artículos de revista
DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista

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