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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neurofarmacología y conducta > DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista >

Involvement of an altered 5-HT -{6} receptor function in behavioral symptoms of Alzheimer's disease
Authors: Marcos, B. (Beatriz)
Garcia-Alloza, M. (Mónica)
Gil-Bea, F.J. (Francisco J.)
Chuang, T.T. (Tsu T.)
Francis, P.T. (Paul T.)
Chen, C.P. (Christopher P.)
Tsang, S.W.T.Y. (Shirley W.T.Y.)
Lai, M.K. (Mitchell K.)
Ramirez, M.J. (María Javier)
Keywords: Adenylate cyclase
Gender
Neocortex
Psychosis
Issue Date: 2008
Publisher: Ios Press
Publisher version: http://www.swetswise.com/eAccess/viewAbstract.do?articleID=37117018&titleID=110691
ISSN: 1875-8908
Citation: Marcos B, Garcia-Alloza M, Gil-Bea FJ, Chuang TT, Francis PT, Chen CP, et al. Involvement of an altered 5-HT -{6} receptor function in behavioral symptoms of Alzheimer's disease. J Alzheimers Dis 2008 May;14(1):43-50.
Abstract
We studied the hypothesis that disturbances in 5-HT_{6} receptor function in the temporal cortex may contribute to clinical symptoms of Alzheimer's disease (AD). 5-HT_{6} density and 5-HT levels were significantly decreased in a cohort of AD patients prospectively assessed for cognitive/behavioral symptoms. cAMP formation after stimulation with the selective 5-HT_{6} receptor agonist E-6801 was significantly lower (p<0.01) in AD (170.02 +/- 27.53 pmol/mg prot.) compared to controls (823.33 +/-196.67). In addition, the ratio cAMP formation after stimulation with E-6801/5-HT_{6} receptor density was significantly lower (p< 0.01) in AD (6.67 +/- 0.83) compared to controls (16.67 +/- 3.33). Splitting these results by sex, 5-HT_{6} receptor activation was significantly lower (p< 0.01) in AD females compared to males (121.67 +/- 30.02 vs. 231.67 +/- 34.17 pmol/mg prot). 5-HT_{6} density and 5-HT levels were significantly correlated (p < or = 0.01) in both controls and AD patients, although in AD, this correlation was lost in females. Psychosis factor was the best predictor of reduced 5-HT levels or adenylate cyclase activity after E-6801 stimulation, the former result being due to females. It may be suggested that psychotic symptoms may be related to a dysregulation of 5-HT_{6} activation by 5-HT in the temporal cortex. These results are discussed in terms of purported influence of sex and therapeutical approaches to psychosis in AD.
Permanent link: http://hdl.handle.net/10171/20227
Appears in Collections:DA - Farmacia - Farmacología - Artículos de revista
DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista

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