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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neurofarmacología y conducta > DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista >

Increase of locomotor activity underlying the behavioral disinhibition in tg2576 mice
Authors: Gil-Bea, F. (Francisco J.)
Aisa, B. (Bárbara)
Schliebs, R. (Reinhard)
Ramirez, M.J. (María Javier)
Keywords: Alzheimer Disease/genetics
Alzheimer Disease/psychology
Behavior, Animal/physiology
Motor Activity/physiology
Issue Date: 2007
Publisher: American Psychological Association
Publisher version: http://psycnet.apa.org/?&fa=main.doiLanding&doi=10.1037/0735-7044.121.2.340
ISSN: 1939-0084
Citation: Gil-Bea FJ, Aisa B, Schliebs R, Ramirez MJ. Increase of locomotor activity underlying the behavioral disinhibition in tg2576 mice. Behav Neurosci 2007 Apr;121(2):340-344.
Abstract
The transgenic Tg2576 mouse is a widely used animal model that develops some of the cognitive and neuropathological deteriorations observed in patients suffering Alzheimer's disease. The authors investigated 9-month-old Tg2576 mice with respect to behavioral and endocrinological (hypothalamic- pituitary-adrenal [HPA] axis activity) parameters. The locomotor activity test revealed that Tg2576 mice moved almost twice as much as controls. Tg2576 mice spent significantly more time visiting the open arms and performed more entries into these open arms than did controls. However, the amount of time that Tg2576 mice remained in each entry to the open arm was similar to that of controls, and the number of arm entries correlated positively to locomotor activity. In the forced swimming test, Tg2576 mice showed a significant decrease in immobility time, which correlated negatively to locomotor activity. Parameters of the HPA axis, such as plasma level of corticosterone, adrenal gland weight, and noradrenaline or adrenaline release, did not differ between controls and Tg2576 mice. These data suggest that the disinhibitory behavior of Tg2576 mice seems to be related to increased locomotor activity but not to any disturbance of the HPA axis.
Permanent link: http://hdl.handle.net/10171/20229
Appears in Collections:DA - Farmacia - Farmacología - Artículos de revista
DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista

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