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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neurofarmacología y conducta > DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista >

Increased sensitivity to MPTP in human alpha-synuclein A30P transgenic mice
Authors: Nieto, M. (María)
Gil-Bea, F. (Francisco J.)
Dalfo, E. (Esther)
Cuadrado-Tejedor, M. (Mar)
Cabodevilla, F. (Felipe)
Sanchez, B. (Belén)
Catena, S. (Silvia)
Sesma, T. (Teresa)
Ribe, E. (Elena M.)
Ferrer, I. (Isidro)
Ramirez, M.J. (María Javier)
Gomez-Isla, T. (Teresa)
Keywords: MPTP
Rotenone
Synuclein
Transgenic mice
Parkinson’s disease
Lewy body
Tyrosine hydroxylase
Substantia nigra
Dopamine
Issue Date: 2006
Publisher: Elsevier
Publisher version: http://dx.doi.org/10.1016/j.neurobiolaging.2005.04.010
ISSN: 1558-1497
Citation: Nieto M, Gil-Bea FJ, Dalfo E, Cuadrado M, Cabodevilla F, Sanchez B, et al. Increased sensitivity to MPTP in human alpha-synuclein A30P transgenic mice. Neurobiol Aging 2006 Jun;27(6):848-856.
Abstract
In addition to genetic factors, environmental factors have long been suspected to contribute to the pathogenesis of Parkinson's disease (PD). We investigated the possible interaction between genetic factors and neurotoxins by testing whether alpha-synuclein A30P Tg5093 transgenic mice show increased sensitivity to secondary toxic insults like 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or rotenone. While sensitivity to chronic treatment with rotenone was not enhanced in the Tg5093 line, chronic treatment with 80 or 150 mg/kg MPTP resulted in increased deterioration of the nigrostriatal dopaminergic system as assessed by quantitation of nigral tyrosine hydroxylase (TH) positive neurons and striatal dopamine (DA) levels in Tg5093 mice when compared to non-transgenic littermate controls. Thus, the results of this study demonstrate a role for the overexpression of mutant human alpha-synuclein A30P in increased vulnerability of DA neurons to MPTP.
Permanent link: http://hdl.handle.net/10171/20231
Appears in Collections:DA - Farmacia - Farmacología - Artículos de revista
DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista

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