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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Neurociencias > Neurofarmacología y conducta > DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista >

Involvement of the GABAergic system in depressive symptoms of Alzheimer's disease
Authors: Garcia-Alloza, M. (Mónica)
Tsang, S.W.T.Y. (Shirley W.T.Y.)
Gil-Bea, F. (Francisco J.)
Francis, P.T. (Paul T.)
Lai, M.K. (Mitchell K.)
Marcos, B. (Beatriz)
Chen, C.P. (Christopher P.)
Ramirez, M.J. (María Javier)
Keywords: Cognitive deficit
Behavioral and psychological syndromes of dementia (BPSD)
GABA
Cortex
Glutamate
GABAa receptors
GABAb receptors
Benzodiazepine receptors
Choline acetyltransferase (ChAT)
Issue Date: 2005
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/S0197458005001727
ISSN: 1558-1497
Citation: Garcia-Alloza M, Tsang SW, Gil-Bea FJ, Francis PT, Lai MK, Marcos B, et al. Involvement of the GABAergic system in depressive symptoms of Alzheimer's disease. Neurobiol Aging 2006 Aug;27(8):1110-1117.
Abstract
Cognitive and neuropsychiatric (BPSD) symptoms seen in Alzheimer's disease (AD) probably result from differential neurotransmitter alterations. The involvement of the glutamatergic and GABAergic system in cognitive and behavioral and psychological symptoms of dementia (BPSD) has been studied in post-mortem frontal and temporal cortex from AD patients who had been prospectively assessed with the Mini-Mental State Examination (MMSE) for cognitive impairment and with the Present Behavioral Examination (PBE) for BPSD. In addition to cholinergic deficits, significant decreases in gamma-amino butyric acid (GABA) content, with no changes in glutamate content, were found in frontal and temporal cortex. Both GABA levels and the glutamate/GABA ratio showed significant correlations with depression in AD. In the temporal cortex, higher densities of GABA(A)/benzodiazepine receptors also correlated with more severe depression. It can be suggested that in a situation of cholinergic deficit, such as AD, an imbalance between the excitatory glutamatergic tone and inhibitory GABAergic tone may be responsible for non-cognitive behavioral disturbances.
Permanent link: http://hdl.handle.net/10171/20233
Appears in Collections:DA - Farmacia - Farmacología - Artículos de revista
DA - CIMA - Neurociencias - Neurofarmacología y conducta - Artículos de Revista

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