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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Anticuerpos monoclonales > DA - CIMA - Terapia génica y Hepatología - Anticuerpos monoclonales - Artículos de Revista >

Leptin gene transfer into muscle increases lipolysis and oxygen consumption in white fat tissue in ob/ob mice
Authors: Marti, A. (Amelia)
Novo, F.J. (Francisco Javier)
Martinez-Anso, E. (Eduardo)
Zaratiegui, M. (Mikel)
Aguado, M. (Miriam)
Martinez, A. (Alfredo)
Keywords: Adipose Tissue/metabolism
Gene Transfer Techniques
Proteins/genetics
Leptin
Issue Date: 1998
Publisher: Elsevier
Publisher version: http://dx.doi.org/10.1006/bbrc.1998.8539
ISSN: 0006-291X
Citation: Marti A, Novo FJ, Martinez-Anso E, Zaratiegui M, Aguado M, Martinez JA. Leptin gene transfer into muscle increases lipolysis and oxygen consumption in white fat tissue in ob/ob mice. Biochem Biophys Res Commun 1998 May 29;246(3):859-862.
Abstract
The effects of leptin production in ob/ob mice injected with a plasmid expression vector containing mouse leptin cDNA in the tibialis anterior muscle were investigated. A significant reduction in food intake (-18%, p < 0.01) along the experimental period was found after DNA injection, while differences in body weight gain were only significant (-41%, p < 0.05) when determined between days 2.9 of the study. Concerning adipocytes metabolism, there was a significant increase in oxygen consumption in vitro (+34%, p < 0.05) and in basal lipolysis (+151%, p < 0.05) in DNA-injected mice compared to PBS-injected animals. Our results confirm that functional leptin can be produced in muscle and released into the blood stream and give new support to the fact that leptin may have direct auto- or paracrine effects on adipocytes, possible contributing to the weight- and fat-reducing effects of leptin in ob/ob mice.
Permanent link: http://hdl.handle.net/10171/20326
Appears in Collections:DA - CIMA - Terapia génica y Hepatología - Anticuerpos monoclonales - Artículos de Revista

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