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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Anticuerpos monoclonales > DA - CIMA - Terapia génica y Hepatología - Anticuerpos monoclonales - Artículos de Revista >

Effect of a beta3-adrenergic agonist on liver glucokinase gene expression in alloxan-diabetic rats
Authors: Milagro, F.I. (Fermín I.)
Gomez-Ambrosi, J. (Javier)
Martinez-Anso, E. (Eduardo)
Martinez, A. (Alfredo)
Keywords: Adrenergic beta-Agonists/pharmacology
Benzyl Alcohols/pharmacology
Diabetes Mellitus, Experimental/enzymology
Gene Expression Regulation, Enzymologic/drug effects
Issue Date: 1999
Publisher: Springer Verlag
ISSN: 1138-7548
Citation: Milagro FI, Gomez-Ambrosi J, Martinez-Anso E, Martinez JA. Effect of a beta3-adrenergic agonist on liver glucokinase gene expression in alloxan-diabetic rats. J Physiol Biochem 1999 Mar;55(1):25-31.
Abstract
Beta-adrenergic agonists have been shown to elicit powerful hypoglycemic effects when administered to different animal models of diabetes. However, the intimate mechanism involved in this process remains unclear. In this context, treatment of alloxan-induced diabetic rats with the beta3-adrenergic agonist Trecadrine (1 mg x kg(-1) x day(-1), s. c.) for four days, normalized glycemia with no changes in plasma insulin levels. Liver glucokinase, a key enzyme in the regulation of glucose storage in hepatocytes, whose gene expression is significantly decreased in alloxan-diabetic rodents, showed a recovery in its mRNA levels after Trecadrine administration. These data suggest that beta3-adrenergic agonists enhance glucose storage in liver, probably through a non-insulin dependent mechanism of action.
Permanent link: http://hdl.handle.net/10171/20330
Appears in Collections:DA - CIFA - Laboratorio de investigación metabólica - Artículos de Revista
DA - CIMA - Terapia génica y Hepatología - Anticuerpos monoclonales - Artículos de Revista

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