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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Inmunología hepatitis virales > DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista >

Tumor therapy in mice by using a tumor antigen linked to modulin peptides from Staphylococcus epidermidis
Authors: Durantez, M. (Maika)
Fayolle, C. (Catherine)
Casares, N. (Noelia)
Belsue, V. (Virginia)
Riezu-Boj, J.I. (José Ignacio)
Sarobe, P. (Pablo)
Prieto, J. (Jesús)
Borras-Cuesta, F. (Francisco)
Leclerc, C. (Claude)
Lasarte, J.J. (Juan José)
Keywords: T-cells
Denditrics cells
Vaccination
Peptides
Antigen targeting
Issue Date: 2010
Publisher: Elsevier
Publisher version: http://dx.doi.org/10.1016/j.vaccine.2010.08.070
ISSN: 0264-410X,
Citation: Durantez M, Fayolle C, Casares N, Belsue V, Riezu-Boj JI, Sarobe P, et al. Tumor therapy in mice by using a tumor antigen linked to modulin peptides from Staphylococcus epidermidis. Vaccine 2010 Oct 18;28(44):7146-7154.
Abstract
Staphylococcus epidermidis releases a complex of at least four peptides, termed phenol-soluble modulins (PSM), which stimulate macrophages to produce proinflammatory cytokines via activation of TLR2 signalling pathway. We demonstrated that covalent linkage of PSM peptides to an antigen facilitate its capture by dendritic cells and, in combination with different TLR ligands, can favour the in vivo induction of strong and persistent antigen-specific immune responses. Treatment of mice grafted with HPV16-E7-expressing tumor cells (TC-1) with poly(I:C) and a peptide containing αMod linked to the H-2D(b)-restricted cytotoxic T-cell epitope E7(49-57) from HPV16-E7 protein allowed complete tumor regression in 100% of the animals. Surprisingly, this immunomodulatory property of modulin-derived peptides was TLR2 independent and partially dependent upon the EGF-receptor signalling pathway. Our results suggest that alpha or gamma modulin peptides may serve as a suitable antigen carrier for the development of anti-tumoral or anti-viral vaccines.
Permanent link: http://hdl.handle.net/10171/20366
Appears in Collections:DA - CUN - Medicina interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Virología - Artículos de revista
DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología experimental - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista

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