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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Inmunología terapia génica > DA - CIMA - Terapia génica y Hepatología - Inmunología terapia génica - Artículos de revista >

Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8
Authors: Feijoo, E. (Esperanza)
Alfaro, C. (Carlos)
Mazzolini, G. (Guillermo)
Serra, P. (Patricia)
Peñuelas, I. (Iván)
Arina, A. (Ainhoa)
Huarte, E. (Eduardo)
Tirapu, I. (Íñigo)
Palencia, B. (Belén)
Murillo, O. (Oihana)
Ruiz, J. (Juan)
Sangro, B. (Bruno)
Richter, J.A. (José Ángel)
Prieto, J. (Jesús)
Melero, I. (Ignacio)
Keywords: IL-8
Dendritic cells
Immunotherapy
Chemotaxis
Cancer
Issue Date: 2005
Publisher: Wiley Blackwell
Publisher version: http://onlinelibrary.wiley.com/doi/10.1002/ijc.21046/abstract
ISSN: 1097-0215
Citation: Feijoo E, Alfaro C, Mazzolini G, Serra P, Penuelas I, Arina A, et al. Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8. Int J Cancer 2005 Aug 20;116(2):275-281.
Abstract
In the course of a clinical trial consisting of intratumoral injections of dendritic cells (DCs) transfected to produce interleukin-12, the use of (111)In-labeled tracing doses of DCs showed that most DCs remained inside tumor tissue, instead of migrating out. In search for factors that could explain this retention, it was found that tumors from patients suffering hepatocellular carcinoma, colorectal or pancreatic cancer were producing IL-8 and that this chemokine attracted monocyte-derived dendritic cells that uniformly express both IL-8 receptors CXCR1 and CXCR2. Accordingly, neutralizing antihuman IL-8 monoclonal antibodies blocked the chemotactic attraction of DCs by recombinant IL-8, as well as by the serum of the patients or culture supernatants of human colorectal carcinomas. In addition, tissue culture supernatants of colon carcinoma cells inhibited DC migration induced by MIP-3beta in an IL-8-dependent fashion. IL-8 production in malignant tissue and the responsiveness of DCs to IL-8 are a likely explanation of the clinical images, which suggest retention of DCs inside human malignant lesions. Impairment of DC migration toward lymphoid tissue could be involved in cancer immune evasion.
Permanent link: http://hdl.handle.net/10171/20414
Appears in Collections:DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología terapia génica - Artículos de revista

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