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Methodological approaches to assess body-weight regulation and aetiology of obesity
Authors: Marti, A. (Amelia)
Miguel, C. (Carlos) de
Jebb, S.A. (Susan A.)
Lafontan, M. (Max)
Laville, M. (Martine)
Palou, A. (Andreu)
Remesar, X. (Xavier)
Trayhurn, P. (Paul)
Martinez, J.A. (José Alfredo)
Keywords: Obesity genes
Adipose tissue
Energy expenditure
Body composition
Issue Date: 2000
Publisher: Cambridge University Press
Publisher version: http://dx.doi.org/10.1017/S0029665100000458
ISSN: 0029-6651
Citation: Marti A, De Miguel C, Jebb SA, Lafontan M, Laville M, Palou A, et al. Methodological approaches to assess body-weight regulation and aetiology of obesity. Proc Nutr Soc. 2000 Aug;59(3):405-11.
Abstract
Obesity, which is becoming one of the major health hazards in developed and developing societies, results from a long-term positive energy balance. Body-weight regulation and stability depend on an axis with three interrelated components: food intake, energy expenditure and adipogenesis, although there are still many unknown features concerning fuel homeostasis and energy balance. Biochemical processes are interconnected, and a separate consideration of each component is often useful for methodological purposes and to achieve a better understanding of the whole system. Thus, many different experimental approaches can be applied by using laboratory animals, cell culture or human subjects to unravel the molecular mechanisms which participate in body-weight regulation. Thus, both in vitro (cellular and subcellular models) and in vivo methods have dramatically increased our knowledge of weight control. Several strategies in obesity research are reported here, exploiting the opportunities of the molecular era as well as novel whole-body approaches, which will impact on the development of new targets for obesity management and prevention.
Permanent link: http://hdl.handle.net/10171/21208
Appears in Collections:DA - Farmacia - CAFT - Artículos de revista

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