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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Hepatología bioquímica > DA - CIMA - Terapia génica y Hepatología - Hepatología bioquímica - Artículos de revista >

Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma
Authors: Berasain, C. (Carmen)
Hevia, H. (Henar)
Fernandez-Irigoyen, J. (Jokin)
Larrea, E. (Esther)
Caballeria, J. (Juan)
Mato, J.M. (José María)
Prieto, J. (Jesús)
Corrales, F.J. (Fernando José)
Garcia-Trevijano, E.R. (Elena R.)
Avila, M.A. (Matías Antonio)
Keywords: Liver
Methylthioadenosine phosphorylase
Cirrhosis
Hepatocarcinoma
Gene expression
Issue Date: 2004
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/S0925443904001371
ISSN: 0006-3002
Citation: Berasain C, Hevia H, Fernandez-Irigoyen J, Larrea E, Caballeria J, Mato JM, et al. Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma. Biochim Biophys Acta 2004 Nov 5;1690(3):276-284.
Abstract
Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine and adenine salvage pathways. In mammals, the liver plays a central role in methionine metabolism, and this essential function is lost in the progression from liver cirrhosis to hepatocarcinoma. Deficient MTAP gene expression has been recognized in many transformed cell lines and tissues. In the present work, we have studied the expression of MTAP in human and experimental liver cirrhosis and hepatocarcinoma. We observe that MTAP gene expression is significantly reduced in human hepatocarcinoma tissues and cell lines. Interestingly, MTAP gene expression was also impaired in the liver of CCl4-cirrhotic rats and cirrhotic patients. We provide evidence indicating that epigenetic mechanisms, involving DNA methylation and histone deacetylation, may play a role in the silencing of MTAP gene expression in hepatocarcinoma. Given the recently proposed tumor suppressor activity of MTAP, our observations can be relevant to the elucidation of the molecular mechanisms of multistep hepatocarcinogenesis.
Permanent link: http://hdl.handle.net/10171/21382
Appears in Collections:DA - CIMA - Terapia génica y Hepatología - Inmunología clínica - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Oncobiología - Artículos de revista
DA - CIMA - Unidad de Proteómica, Genómica y Bioinformática - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Hepatología bioquímica - Artículos de revista

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