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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Hepatología bioquímica > DA - CIMA - Terapia génica y Hepatología - Hepatología bioquímica - Artículos de revista >

Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury
Authors: Martinez-Chantar, M.L. (María Luz)
Garcia-Trevijano, E.R. (Elena R.)
Latasa, M.U. (María Ujué)
Perez-Mato, I. (Isabel)
Sanchez del Pino, M.M. (Manuel M.)
Corrales, F.J. (Fernando José)
Avila, M.A. (Matías Antonio)
Mato, J.M. (José María)
Keywords: Methionine
S-adenosyl-l-methionine
SAMe
Methionine adenosyltransferase
Liver injury
Liver regeneration
Cirrhosis
Oxidative stress
Protein S-nitrosylation
Issue Date: 2002
Publisher: American Society for Nutrition
Publisher version: http://www.ajcn.org/content/76/5/1177S
ISSN: 1938-3207
Citation: Martinez-Chantar ML, Garcia-Trevijano ER, Latasa MU, Perez-Mato I, Sanchez del Pino MM, Corrales FJ, et al. Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury. Am J Clin Nutr 2002 Nov;76(5):1177S-82S.
Abstract
One of the features of liver cirrhosis is an abnormal metabolism of methionine--a characteristic that was described more than a half a century ago. Thus, after an oral load of methionine, the rate of clearance of this amino acid from the blood is markedly impaired in cirrhotic patients compared with that in control subjects. Almost 15 y ago we observed that the failure to metabolize methionine in cirrhosis was due to an abnormally low activity of the enzyme methionine adenosyltransferase (EC 2.5.1.6). This enzyme converts methionine, in the presence of ATP, to S-adenosyl-L-methionine (SAMe), the main biological methyl donor. Since then, it has been suspected that a deficiency in hepatic SAMe may contribute to the pathogenesis of the liver in cirrhosis. The studies reviewed here are consistent with this hypothesis.
Permanent link: http://hdl.handle.net/10171/21479
Appears in Collections:DA - CIMA - Unidad de Proteómica, Genómica y Bioinformática - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Hepatología bioquímica - Artículos de revista

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