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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Hepatología bioquímica > DA - CIMA - Terapia génica y Hepatología - Hepatología bioquímica - Artículos de revista >

Toward the discovery of new biomarkers of hepatocellular carcinoma by proteomics
Authors: Santamaria, E. (Enrique)
Muñoz, J. (Javier)
Fernandez-Irigoyen, J. (Joaquín)
Prieto, J. (Jesús)
Corrales, F.J. (Fernando José)
Keywords: Biomarkers
Hepatocellular carcinoma
Mass spectrometry
Proteomics
Issue Date: 2007
Publisher: John Wiley and Sons
Publisher version: http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2007.01447.x/abstract
ISSN: 1478-3231
Citation: Santamaria E, Munoz J, Fernandez-Irigoyen J, Prieto J, Corrales FJ. Toward the discovery of new biomarkers of hepatocellular carcinoma by proteomics. Liver Int 2007 Mar;27(2):163-173.
Abstract
Primary liver cancer is the fifth most frequent neoplasm and the third most common cause of cancer-related death, with more than 500,000 new cases diagnosed yearly. The outcome for hepatocellular carcinoma (HCC) patients still remains dismal, partly because of our limited knowledge of its molecular pathogenesis and the difficulty in detecting the disease at its early stages. Therefore, studies aimed at the definition of the mechanisms associated with HCC progression and the identification of new biomarkers leading to early diagnosis and more effective therapeutic interventions are urgently needed. Proteomics is a rapidly expanding discipline that is expected to change the way in which diseases will be diagnosed, treated, and monitored in the near future. In the last few years, HCC has been extensively investigated using different proteomic approaches on HCC cell lines, animal models, and human tumor tissues. In this review, state-of-the-art technology on proteomics is overviewed, and recent advances in liver cancer proteomics and their clinical projections are discussed.
Permanent link: http://hdl.handle.net/10171/21568
Appears in Collections:DA - CIMA - Unidad de Proteómica, Genómica y Bioinformática - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Hepatología bioquímica - Artículos de revista

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