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Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection
Authors: Larrea, E. (Esther)
Riezu-Boj, J.I. (José Ignacio)
Gil-Guerrero, L. (Lucía)
Casares, N. (Noelia)
Aldabe, R. (Rafael)
Sarobe, P. (Pablo)
Civeira, M.P. (María Pilar)
Heeney, J.L. (Jonathan L.)
Rollier, C.S. (Christine S.)
Verstrepen, B. (Babs)
Keywords: Gene Expression Regulation, Enzymologic
Hepatitis C/enzymology
Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism
Issue Date: 2007
Publisher: American Society for Microbiology
Publisher version: http://jvi.asm.org/content/81/7/3662
ISSN: 1098-5514
Citation: Larrea E, Riezu-Boj JI, Gil-Guerrero L, Casares N, Aldabe R, Sarobe P, et al. Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection. J Virol 2007 Apr;81(7):3662-3666.
Abstract
Indoleamine 2,3-dioxygenase (IDO) is induced by proinflammatory cytokines and by CTLA-4-expressing T cells and constitutes an important mediator of peripheral immune tolerance. In chronic hepatitis C, we found upregulation of IDO expression in the liver and an increased serum kynurenine/tryptophan ratio (a reflection of IDO activity). Huh7 cells supporting hepatitis C virus (HCV) replication expressed higher levels of IDO mRNA than noninfected cells when stimulated with gamma interferon or when cocultured with activated T cells. In infected chimpanzees, hepatic IDO expression decreased in animals that cured the infection, while it remained high in those that progressed to chronicity. For both patients and chimpanzees, hepatic expression of IDO and CTLA-4 correlated directly. Induction of IDO may dampen T-cell reactivity to viral antigens in chronic HCV infection
Permanent link: http://hdl.handle.net/10171/21602
Appears in Collections:DA - CIMA - Terapia génica y Hepatología - Inmunología clínica - Artículos de revista
DA - CUN - Medicina interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Virología - Artículos de revista
DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología experimental - Artículos de revista

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