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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Inmunología experimental > DA - CIMA - Terapia génica y Hepatología - Inmunología experimental - Artículos de revista >

Overcoming class II-linked non-responsiveness to hepatitis B vaccine
Authors: Hervas-Stubbs, S. (Sandra)
Berasain, C. (Carmen)
Golvano, J.J. (José Javier)
Lasarte, J.J. (Juan José)
Prieto, I. (Isidro)
Sarobe, P. (Pablo)
Prieto, J. (Jesús)
Borras-Cuesta, F. (Francisco)
Keywords: Hepatitis B surface antigen
T-cell help
Hepatitis B vaccine
Induction of antibodies
Synthetic peptides
Issue Date: 1994
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/0264410X94900264
ISSN: 1873-2518
Citation: Hervas-Stubbs S, Berasain C, Golvano JJ, Lasarte JJ, Prieto I, Sarobe P, et al. Overcoming class II-linked non-responsiveness to hepatitis B vaccine. Vaccine 1994 Aug;12(10):867-871.
Abstract
This work shows that class II-linked humoral lack of response to an antigen can be overcome by joint immunization with the antigen and a T-helper cell determinant (TDh) well recognized by class II molecules of a non-responder individual. Thus, SJL/J mice (H-2s), which are non-responders to the S region of hepatitis B virus surface antigen (HBsAg), were rendered responders by joint immunization with a recombinant surface antigen, only composed of the S region, and a short synthetic TDh peptide well recognized by the H-2s restriction. By contrast, when this peptide is not recognized as TDh, as in B10M mice (H-2f restricted and also non-responders to the S region), no humoral response could be induced against the S region. These results have important implications for therapy and vaccination against hepatitis B virus as well as in enhancing the immunogenicity of other antigens.
Permanent link: http://hdl.handle.net/10171/21603
Appears in Collections:DA - CIMA - Terapia génica y Hepatología - Oncobiología - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología terapia génica - Artículos de revista
DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología experimental - Artículos de revista

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