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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Inmunología experimental > DA - CIMA - Terapia génica y Hepatología - Inmunología experimental - Artículos de revista >

CD4-modified synthetic peptides containing phenylalanine inhibit HIV-1 infection in vitro
Authors: Lasarte, J.J. (Juan José)
Sarobe, P. (Pablo)
Golvano, J.J. (José Javier)
Prieto, I. (Isidro)
Civeira, M.P. (María Pilar)
Gullon, A. (Arturo)
Sarin, P.S. (Prem S.)
Prieto, J. (Jesús)
Borras-Cuesta, F. (Francisco)
Keywords: HIV-1/drug effects
Peptides/pharmacology
Phenylalanine/chemistry
Viral Proteins
Issue Date: 1994
Publisher: Lippincott, Williams & Wilkins
Publisher version: http://bit.ly/HeCxzF
ISSN: 1944-7884
Citation: Lasarte JJ, Sarobe P, Golvano J, Prieto I, Civeira MP, Gullon A, et al. CD4-modified synthetic peptides containing phenylalanine inhibit HIV-1 infection in vitro. J Acquir Immune Defic Syndr 1994 Feb;7(2):129-134.
Abstract
Phenylalanine-containing peptides from CD4 were synthesized based on chemical similarity with active CD4(81-92)-benzylated peptides. The synthetic peptide FYIFFVEDQKEEDD blocked the binding of gp120 to CD4 and inhibited 50% human immunodeficiency virus (HIV)-induced syncytia formation at a concentration (IC50) of approximately 40-50 microM and HIV p17 expression with an IC50 of approximately 67 microM. The peptide is not toxic to cells in vitro. Moreover, acute toxicity studies carried out in Swiss mice showed the peptide to be nontoxic at a dose of 2,000 mg/kg. This phenylalanine-substituted CD4 peptide may prove to be useful in the treatment of AIDS.
Permanent link: http://hdl.handle.net/10171/21653
Appears in Collections:DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología experimental - Artículos de revista

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