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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Inmunología experimental > DA - CIMA - Terapia génica y Hepatología - Inmunología experimental - Artículos de revista >

Enhancement of peptide immunogenicity by insertion of a cathepsin B cleavage site between determinants recognized by B and T cells
Authors: Sarobe, P. (Pablo)
Lasarte, J.J. (Juan José)
Larrea, E. (Esther)
Golvano, J.J. (José Javier)
Prieto, I. (Inés)
Gullon, A. (Arturo)
Prieto, J. (Jesús)
Borras-Cuesta, F. (Francisco)
Keywords: Immunogenicity
Peptide
Lysine
B cell
T cell
IL2
Determinant
Cathepsin B
Antigen processing
Issue Date: 1993
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/0923249493801025
ISSN: 0923-2494
Citation: Sarobe P, Lasarte JJ, Larrea E, Golvano JJ, Prieto I, Gullon A, et al. Enhancement of peptide immunogenicity by insertion of a cathepsin B cleavage site between determinants recognized by B and T cells. Res Immunol 1993 May;144(4):257-262.
Abstract
The insertion of two lysine residues (cleavage sites of cathepsin B) at the boundary of a peptide recognized by B cells (BD) and a class-II- presentable sequence (TDh) enhanced the anti-BD antibody induction capacity of this type of peptide construct, as well as production of IL2. It is postulated that these lysines generate a neoprocessable site which helps in release of the TDh moiety from the construct, enabling its presentation to class II molecules, an essential step in clonal expansion of the antibody-producing B cell after internalization of the construct via the BD moiety.
Permanent link: http://hdl.handle.net/10171/21660
Appears in Collections:DA - CIMA - Terapia génica y Hepatología - Inmunología clínica - Artículos de revista
DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología experimental - Artículos de revista

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