Dadun Dadun cabecera universidad cabecera biblioteca
   (New user)
Help  | Contact  |  Castellano English  
 

Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Inmunología hepatitis virales > DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista >

A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury
Authors: Ezquerro, I.J. (Ignacio José)
Lasarte, J.J. (Juan José)
Dotor, J. (Javier)
Castilla-Cortazar, I. (Inma)
Bustos, M. (Matilde)
Peñuelas, I. (Iván)
Blanco, G. (Gemma)
Rodriguez, C. (Carlos)
Lechuga, M.C.G. (María del Carmen G.)
Greenwel, P. (Patricia)
Rojkind, M. (Marcos)
Prieto, J. (Jesús)
Borras-Cuesta, F. (Francisco)
Keywords: Collagen
Flow cytometry
Hepatic stellate cells
Liver cirrhosis
MV1Lu cells
Issue Date: 2003
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/S1043466603001017
ISSN: 1096-0023
Citation: Ezquerro IJ, Lasarte JJ, Dotor J, Castilla-Cortazar I, Bustos M, Penuelas I, et al. A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury. Cytokine 2003 Apr;22(1-2):12-20.
Abstract
Transforming growth factor beta1 (TGF-beta1) is a pleiotropic cytokine, which displays potent profibrogenic effects and is highly expressed in fibrotic livers. For this reason, development of TGF-B1 inhibitors might be of great importance to control liver fibrogenesis as well as other undesired side effects due to this cytokine. Potential peptide inhibitors of TGF-beta1 (derived from TGF-beta1 and from its type III receptor) were tested in vitro and in vivo using different assays. Peptides P11 and P12, derived from TGF-beta1, and P54 and P144, derived from its type III receptor, prevented TGF-beta1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduced binding of TGF-beta1 to its receptors. P144 blocked TGF-beta1-dependent stimulation of a reporter gene under the control of human alpha2(I) collagen promoter. Intraperitoneal administration of P144 also showed potent antifibrogenic activity in vivo in the liver of rats receiving CCl4. These rats also showed a significant decrease in the number of activated hepatic stellate cells as compared with those treated with saline only. These results suggest that short synthetic peptides derived from TGF-beta1 type III receptor may be of value in reducing liver fibrosis in chronic liver injury.
Permanent link: http://hdl.handle.net/10171/21673
Appears in Collections:DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista

Files in This Item:
File:  Cytokine20032212.pdf
Description: 
Size:  3,41 MB
Format:  Adobe PDF
 View / Open 

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.