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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Inmunología experimental > DA - CIMA - Terapia génica y Hepatología - Inmunología experimental - Artículos de revista >

Induction of antibodies against a peptide hapten does not require covalent linkage between the hapten and a class II presentable T helper peptide
Authors: Sarobe, P. (Pablo)
Lasarte, J.J. (Juan José)
Golvano, J.J. (José Javier)
Gullon, A. (Arturo)
Civeira, M.P. (María Pilar)
Prieto, J. (Jesús)
Borras-Cuesta, F. (Francisco)
Keywords: Antibody Formation
Haptens/immunology
Histocompatibility Antigens Class II/immunology
T-Lymphocytes, Helper-Inducer/immunology
Issue Date: 1991
Publisher: Wiley-VCH Verlag Berlin
Publisher version: http://onlinelibrary.wiley.com/doi/10.1002/eji.1830210633/abstract
ISSN: 1521-4141
Citation: Sarobe P, Lasarte JJ, Golvano J, Gullon A, Civeira MP, Prieto J, et al. Induction of antibodies against a peptide hapten does not require covalent linkage between the hapten and a class II presentable T helper peptide. Eur J Immunol 1991 Jun;21(6):1555-1558.
Abstract
Following immunization with a complex antigen, a B cell internalizes this antigen through an interaction between its surface immunoglobulins and an epitope of the antigen. Enzymatic processing of the antigen frees one or more short peptide determinants (TD) which bind to class II molecules of the B cell. If the complex TD-MHC II is recognized by the receptor of a T helper cell, T cell help is provided leading to the expansion of an antibody-producing B cell clone specific for the epitope. We present experimental evidence proving that the induction of anti-peptide hapten antibodies does not require covalent linkage between the peptide hapten and the peptide behaving as TD. Indeed, high anti-peptide hapten antibody titers are induced if an emulsion of TD and hapten are injected in the same immunization site. This result suggests a way to manipulate antibody production with useful applications to research and therapy.
Permanent link: http://hdl.handle.net/10171/21676
Appears in Collections:DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología experimental - Artículos de revista

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