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|Title: ||Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C|
|Author(s) : ||Gavier, B. (B)|
Martinez-Gonzalez, M.A. (Miguel Angel)
Riezu-Boj, J.I. (José Ignacio)
Lasarte, J.J. (Juan José)
García, N. (Nicolás)
Civeira, M.P. (María Pilar)
Prieto, J. (Jesús)
|Issue Date: ||1997|
|Publisher: ||WB Saunders|
|Citation: ||Gavier B, Martinez-Gonzalez MA, Riezu-Boj JI, Lasarte JJ, Garcia N, Civeira MP, et al. Viremia after one month of interferon therapy predicts treatment outcome in patients with chronic hepatitis C. Gastroenterology 1997 Nov;113(5):1647-1653.|
|Keywords: ||Antiviral Agents/therapeutic use|
|Abstract: ||BACKGROUND & AIMS:
In chronic hepatitis C, interferon alfa induces sustained remission in less than 30% of treated patients. The aim of this study is to analyze viral status early after initiation interferon therapy as a predictor of treatment outcome.
One hundred eighty-one patients with chronic hepatitis C who had been treated with interferon alfa for 12 months (median follow-up, 49 months) were studied. Viremia and aminotransferase levels at the first and third months of therapy as well as 10 pretreatment variables were assessed as potential independent predictors of sustained response to treatment.
Sustained response occurred in 51 patients (28%). At month 1 of treatment, viral persistence accurately predicted nonresponse (predictive value, 95.3; 95% confidence interval, 86.0-98.8; P < 0.0001). Independent predictors of sustained response were undetectable viremia at the first month of therapy (P < 0.001), undetectable viremia at the third month (P < 0.001), younger age (P = 0.006), nonsporadic infection (P = 0.012), and higher pretreatment aspartate aminotransferase levels (P = 0.032). In patients who cleared HCV RNA at month 1 of therapy, the predicted probability of sustained response averaged 70% for those younger than 30 years and diminished by 10% for each decade of age.
Failure to clear HCV RNA at month 1 of treatment is strongly and independently associated with a very low probability of a sustained response to interferon.|
|Publisher version (URL): ||http://www.sciencedirect.com/science/article/pii/S0016508597005325|
|Appears in Collections:||DA - CUN - Medicina interna - Artículos de revista|
DA - CIMA - Terapia génica y Hepatología - Virología - Artículos de revista
DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista
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