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Dadun > Depósito Académico > Clínica Universidad de Navarra > Cirugía general y digestiva > DA - CUN - Cirugía general y digestiva - Artículos de revista >

Prognostic model for early acute rejection after liver transplantation
Authors: Gomez-Manero, N. (Noemí)
Herrero, J.I. (José Ignacio)
Quiroga, J. (Jorge)
Sangro, B. (Bruno)
Pardo, F. (Fernando)
Cienfuegos, J.A. (Javier A.)
Prieto, J. (Jesús)
Keywords: Immunosuppressive Agents
Liver Transplantation
Cyclosporine
Calcineurin
Issue Date: 2001
Publisher: Wiley-Blackwell
Publisher version: http://dx.doi.org/10.1053/jlts.2001.22460
ISSN: 1527-6465
Citation: Gomez-Manero N, Herrero JI, Quiroga J, Sangro B, Pardo F, Cienfuegos JA, et al. Prognostic model for early acute rejection after liver transplantation. Liver Transpl 2001 Mar;7(3):246-254.
Abstract
Hepatic graft rejection is a common complication after liver transplantation (LT), with a maximum incidence within the first weeks. The identification of high-risk patients for early acute rejection (EAR) might be useful for clinicians. A series of 133 liver graft recipients treated with calcineurin inhibitors was retrospectively assessed to identify predisposing factors for EAR and develop a mathematical model to predict the individual risk of each patient. The incidence of EAR (< or =45 days after LT) was 35.3%. Multivariate analysis showed that recipient age, underlying liver disease, and Child's class before LT were independently associated with the development of EAR. Combining these 3 variables, the following risk score for the development of EAR was obtained: EAR score [F(x)] = 2.44 + (1.14 x hepatitis C virus cirrhosis) + (2.78 x immunologic cirrhosis) + (2.51 x metabolic cirrhosis)--(0.08 x recipient age in years) + (1.65 x Child's class A) [corrected]. Risk for rejection = e(F(x))/1 + e(F(x)). The combination of age, cause of liver disease, and Child's class may allow us to predict the risk for EAR.
Permanent link: http://hdl.handle.net/10171/21683
Appears in Collections:DA - CUN - Cirugía general y digestiva - Artículos de revista

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