Dadun Dadun cabecera universidad cabecera biblioteca
   (New user)
Help  | Contact  |  Castellano English  
 

Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Inmunología hepatitis virales > DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista >

Inhibitory effect against polymerase and ribonuclease activities of HIV-reverse transcriptase of the aqueous leaf extract of Terminalia triflora
Authors: Martino, V. (Virginia S.)
Lopez, P. (Pedro)
Martinez-Irujo, J.J. (Juan José)
Sanroman, M. (Marcos)
Cuevas, M.T. (María T.)
Santiago, E. (Esteban)
Lasarte, J.J. (Juan José)
Font, M. (María)
Coussio, J.D. (J.D.)
Monge, A. (Antonio)
Keywords: Terminalia triflora
Aqueous extract
AntiHIV-reverse transcriptase activity
Issue Date: 2002
Publisher: John Wiley and Sons
Publisher version: http://onlinelibrary.wiley.com/doi/10.1002/ptr.1065/abstract
ISSN: 1099-1573
Citation: Martino VS, Lopez P, Martinez Irujo JJ, Sanroman M, Cuevas MT, Santiago E, et al. Inhibitory effect against polymerase and ribonuclease activities of HIV-reverse transcriptase of the aqueous leaf extract of Terminalia triflora. Phytother Res 2002 Dec;16(8):778-780.
Abstract
Dichloromethane, methanol and aqueous extracts from the leaves of Terminalia triflora were investigated for their inhibitory effect on polymerase and ribonuclease activities of HIV reverse transcriptase.The most potent activity was found in the aqueous extract, which inhibited both polymerase and ribonuclease activities of the enzyme with an IC50 of 1.6 micro g/mL and 1.8 micro g/mL respectively. The antiinfective activity of the extract was demonstrated in HLT4LacZ-IIIB cell culture with an IC50 of 1.0 micro g/mL. The extract was submitted to a purification process by extractive and chromatographic methods. The activity remained in the hydrophillic fraction. Tannins present in this active purified fraction, as determined by TLC and HPLC methods, could account for the anti HIV-RT activity found in the aqueous extract.
Permanent link: http://hdl.handle.net/10171/21723
Appears in Collections:DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología hepatitis virales - Artículos de revista

Files in This Item:
File:  PhytotherRes200216778.pdf
Description: 
Size:  76,01 kB
Format:  Adobe PDF
 View / Open 

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.