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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Inmunología terapia génica > DA - CIMA - Terapia génica y Hepatología - Inmunología terapia génica - Artículos de revista >

Immunotherapy and immunoescape in colorectal cancer
Authors: Mazzolini, G. (Guillermo)
Murillo, O. (Oihana)
Atorrasagasti, C. (Catalina)
Dubrot, J. (Juan)
Tirapu, I. (Íñigo)
Rizzo, M. (Miguel)
Arina, A. (Ainhoa)
Alfaro, C. (Carlos)
Azpilicueta, A. (Arantza)
Berasain, C. (Carmen)
Perez-Gracia, J.L. (José Luis)
Gonzalez, A. (Alvaro)
Melero, I. (Ignacio)
Keywords: Colorectal carcinoma
Immunotherapy
Gene therapy
Interleukin-12
Dendritic cells
CD137
Indoleamine 2, 3 dioxygenase
Issue Date: 2007
Publisher: Baishideng Publishing
Publisher version: http://www.wjgnet.com/1007-9327/full/v13/i44/5822.htm
ISSN: 2219-2840
Citation: Mazzolini G, Murillo O, Atorrasagasti C, Dubrot J, Tirapu I, Rizzo M, et al. Immunotherapy and immunoescape in colorectal cancer. World J Gastroenterol 2007 Nov 28;13(44):5822-5831.
Abstract
Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNgamma in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.
Permanent link: http://hdl.handle.net/10171/21731
Appears in Collections:DA - CIMA - Terapia génica y Hepatología - Oncobiología - Artículos de revista
DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología terapia génica - Artículos de revista

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