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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Inmunología terapia génica > DA - CIMA - Terapia génica y Hepatología - Inmunología terapia génica - Artículos de revista >

An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas
Authors: Melero, I. (Ignacio)
Gabari, I. (Izaskun)
Corbi, A.L. (Angel L.)
Relloso, M. (Miguel)
Mazzolini, G. (Guillermo)
Schmitz, V. (Volker)
Rodriguez-Calvillo, M. (Mercedes)
Tirapu, I. (Íñigo)
Camafeita, E. (Emilio)
Albar, J.P. (Juan P.)
Prieto, J. (Jesús)
Keywords: Antibodies, Monoclonal/immunology
Antigens, CD/immunology
Cell Adhesion Molecules/immunology
Colonic Neoplasms/immunology
Lectins, C-Type
Issue Date: 2002
Publisher: American Association for Cancer Research
Publisher version: http://cancerres.aacrjournals.org/content/62/11/3167
ISSN: 1538-7445
Citation: Melero I, Gabari I, Corbi AL, Relloso M, Mazzolini G, Schmitz V, et al. An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas. Cancer Res 2002 Jun 1;62(11):3167-3174.
Abstract
Monoclonal antibodies (mAbs) can mediate antitumor effects by indirect mechanisms involving antiangiogenesis and up-regulation of the cellular immune response rather than by direct tumor cell destruction. From mAbs raised by immunization of rats with transformed murine endothelial cells, a mAb (EOL4G8) was selected for its ability to eradicate a fraction of established colon carcinomas that did not express the EOL4G8-recognized antigen. The antigen was found to be ICAM-2 (CD102). Antitumor effects of EOL4G8, which required a functional T-cell compartment, were abrogated by depletion of CD8(+) cells and correlated with antitumor CTL activity, whereas only a mild inhibition of angiogenesis was observed. Interestingly, we found that EOL4G8 acting on endothelial ICAM-2 markedly enhances leukotactic factor activity-1-independent adhesion of immature dendritic cells to endothelium-an effect that is at least in part mediated by DC-SIGN (CD209).
Permanent link: http://hdl.handle.net/10171/21742
Appears in Collections:DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología terapia génica - Artículos de revista

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