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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Inmunología terapia génica > DA - CIMA - Terapia génica y Hepatología - Inmunología terapia génica - Artículos de revista >

IL-12 gene therapy for cancer: in synergy with other immunotherapies
Authors: Melero, I. (Ignacio)
Mazzolini, G. (Guillermo)
Narvaiza, I. (Íñigo)
Qian, C. (Cheng)
Chen, L. (Lieping)
Prieto, J. (Jesús)
Keywords: Gene therapy
Interleukin-12
Immunotherapy
Cancer
Chemokines
Costimulation
Dendritic cells
Issue Date: 2001
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/S147149060001824X
ISSN: 1471-4981
Citation: Melero I, Mazzolini G, Narvaiza I, Qian C, Chen L, Prieto J. IL-12 gene therapy for cancer: in synergy with other immunotherapies. Trends Immunol 2001 Mar;22(3):113-115.
Abstract
In preclinical models of cancer, gene therapy with interleukin 12 (IL-12) has reached unprecedented levels of success when combined with immunotherapy approaches such as gene transfer of other cytokines and/or chemokines, costimulatory molecules or adoptive cell therapy. These combinations have been found to produce synergistic rather than additive effects. Meanwhile, IL-12 gene therapy is beginning clinical testing as a single agent, but combination strategies are at hand.
Permanent link: http://hdl.handle.net/10171/21779
Appears in Collections:DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología terapia génica - Artículos de revista

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