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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Inmunología terapia génica > DA - CIMA - Terapia génica y Hepatología - Inmunología terapia génica - Artículos de revista >

Palettes of vaccines and immunostimulatory monoclonal antibodies for combination
Authors: Melero, I. (Ignacio)
Martinez-Forero, I. (Iván)
Dubrot, J. (Juan)
Suarez, N. (Natalia)
Palazon, A. (Asís)
Chen, L. (Lieping)
Keywords: Antibodies, Monoclonal/therapeutic use
Cancer Vaccines/therapeutic use
Neoplasms/therapy
Issue Date: 2009
Publisher: American Association for Cancer Research
Publisher version: http://clincancerres.aacrjournals.org/content/15/5/1507
ISSN: 1557-3265
Citation: Melero I, Martinez-Forero I, Dubrot J, Suarez N, Palazon A, Chen L. Palettes of vaccines and immunostimulatory monoclonal antibodies for combination. Clin Cancer Res 2009 Mar 1;15(5):1507-1509.
Abstract
Various monoclonal antibodies (mAb) target immune system molecules to enhance immunity by costimulating T cells (i.e., CD137, OX40, CD40, GITR) or interfering in coinhibitory signals (i.e., CTLA-4, PD-1). These powerful agents can be guided by cancer vaccines to enhance immunity against tumor but not self tissues. Clinically powerful therapeutic synergies are at hand.
Permanent link: http://hdl.handle.net/10171/21780
Appears in Collections:DA - Medicina - Medicina Interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología terapia génica - Artículos de revista

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