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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Cardiopatía hipertensiva > DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista >

Upregulation of myocardial Annexin A5 in hypertensive heart disease: association with systolic dysfunction
Authors: Ravassa, S. (Susana)
Gonzalez, A. (Arantxa)
Lopez, B. (Begoña)
Beaumont, J. (Javier)
Querejeta, R. (Ramón)
Larman, M. (Mariano)
Diez, J. (Javier)
Keywords: Annexin A5
Apoptosis
Heart failure
Hypertension
Issue Date: 2007
Publisher: Oxford University Press
Publisher version: http://eurheartj.oxfordjournals.org/content/28/22/2785
ISSN: 1522-9645
Citation: Ravassa S, Gonzalez A, Lopez B, Beaumont J, Querejeta R, Larman M, et al. Upregulation of myocardial Annexin A5 in hypertensive heart disease: association with systolic dysfunction. Eur Heart J 2007 Nov;28(22):2785-2791.
Abstract
AIMS: To investigate whether Annexin A5 (AnxA5) is related to hypertensive heart disease (HHD) and whether this relation is dependent of apoptosis. METHODS AND RESULTS: Hypertensives without cardiac abnormalities (stage A), with left ventricular hypertrophy (LVH) (stage B), and with LVH and clinical manifestations of chronic HF (stage C), were studied. AnxA5 was quantified in endomyocardial biopsies by real time RT-PCR, Western blot, and immunohistochemistry, and apoptosis by DNA fragmentation, caspase-3 activation, and PARP and Bax/Bcl-2 ratios. Plasma AnxA5 was measured by ELISA in samples from the coronary sinus and the antecubital vein. Although AnxA5 mRNA did not change, myocardial and plasma AnxA5 were increased in hypertensives stages B and C compared with normotensives and hypertensives stage A. Myocardial AnxA5 was inversely correlated with parameters assessing systolic function in all hypertensives, this association being independent of apoptosis. Myocardial AnxA5 was directly correlated with plasma AnxA5. Plasma AnxA5 was inversely correlated with systolic function in all hypertensives. CONCLUSION: This cross-sectional study shows that myocardial AnxA5 upregulation is associated with HHD and impairment of systolic function in hypertensive patients, this association being independent of apoptosis. Plasma AnxA5 can be a marker of myocardial AnxA5 upregulation and systolic dysfunction in patients with HHD.
Permanent link: http://hdl.handle.net/10171/21866
Appears in Collections:DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista

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