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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Cardiopatía hipertensiva > DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista >

The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data
Authors: Dzau, V.J. (Victor J.)
Bernstein, K. (Kenneth)
Celermajer, D. (David)
Cohen, J. (Jerome)
Dahlöf, B. (Björn)
Deanfield, J. (John)
Diez, J. (Javier)
Drexler, H. (Helmut)
Ferrari, R. (Roberto)
Van-Gilst, W. (Wiek)
Hansson, L. (Lennart)
Hornig, B. (Burkhard)
Husain, A. (Ahsan)
Johnston, C. (Colin)
Lazar, H. (Harold)
Lonn, E. (Eva)
Lüscher, T. (Thomas)
Mancini, J. (John)
Mimran, A. (Albert)
Pepine, C. (Carl)
Rabelink, T. (Ton)
Remme, W. (Willem)
Ruilope, L.M. (Luis M.)
Ruzicka, M. (Marcel)
Schunkert, H. (Heribert)
Swedberg, K. (Karl)
Unger, T. (Thomas)
Vaughan, D. (Douglas)
Weber, M. (Michael)
Keywords: Peptidyl-Dipeptidase A/physiology
Issue Date: 2001
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/S0002914901018781
ISSN: 1879-1913
Citation: Dzau VJ, Bernstein K, Celermajer D, Cohen J, Dahlof B, Deanfield J, et al. The relevance of tissue angiotensin-converting enzyme: manifestations in mechanistic and endpoint data. Am J Cardiol 2001 Nov 8;88(9A):1L-20L.
Abstract
Angiotensin-converting enzyme (ACE) is primarily localized (>90%) in various tissues and organs, most notably on the endothelium but also within parenchyma and inflammatory cells. Tissue ACE is now recognized as a key factor in cardiovascular and renal diseases. Endothelial dysfunction, in response to a number of risk factors or injury such as hypertension, diabetes mellitus, hypercholesteremia, and cigarette smoking, disrupts the balance of vasodilation and vasoconstriction, vascular smooth muscle cell growth, the inflammatory and oxidative state of the vessel wall, and is associated with activation of tissue ACE. Pathologic activation of local ACE can have deleterious effects on the heart, vasculature, and the kidneys. The imbalance resulting from increased local formation of angiotensin II and increased bradykinin degradation favors cardiovascular disease. Indeed, ACE inhibitors effectively reduce high blood pressure and exert cardio- and renoprotective actions. Recent evidence suggests that a principal target of ACE inhibitor action is at the tissue sites. Pharmacokinetic properties of various ACE inhibitors indicate that there are differences in their binding characteristics for tissue ACE. Clinical studies comparing the effects of antihypertensives (especially ACE inhibitors) on endothelial function suggest differences. More comparative experimental and clinical studies should address the significance of these drug differences and their impact on clinical events.
Permanent link: http://hdl.handle.net/10171/21895
Appears in Collections:DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista

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