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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Cardiopatía hipertensiva > DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista >

Independent association of fibrinogen with carotid intima-media thickness in asymptomatic subjects
Authors: Martinez-Vila, E. (Eduardo)
Paramo, J.A. (José Antonio)
Beloqui, O. (Óscar)
Orbe, J. (Josune)
Irimia, P. (Pablo)
Colina, I. (Inmaculada)
Monreal, J.I. (José Ignacio)
Benito, A. (Alberto)
Barba, J. (Joaquín)
Zubieta, J.L. (José L.)
Diez, J. (Javier)
Keywords: Fibrinogen
Polymorphisms
Atherosclerosis
Carotid intima-media thickness
Issue Date: 2003
Publisher: Karger
Publisher version: http://content.karger.com/produktedb/produkte.asp?DOI=10.1159/000072557
ISSN: 1421-9786
Citation: Martinez-Vila E, Paramo JA, Beloqui O, Orbe J, Irimia P, Colina I, et al. Independent association of fibrinogen with carotid intima-media thickness in asymptomatic subjects. Cerebrovasc Dis 2003;16(4):356-362.
Abstract
BACKGROUND: Fibrinogen has been found to be an independent risk factor for cardiovascular disease. Both genetic and environmental factors contribute to its variability in plasma. However, whether the relation between fibrinogen and carotid intima-media thickness (IMT) is independent of those factors has not been established. Therefore, the aim of this study was to investigate the relations of plasma fibrinogens and the -455 G/A Bbeta-fibrinogen polymorphism with the carotid IMT in a series of asymptomatic subjects. METHODS: Markers of inflammation, C-reactive protein (CRP) and leukocytes, and endothelial perturbation (von Willebrand factor, vWF) were measured in 135 subjects. All individuals underwent a complete clinical examination and lipid measurements (cholesterol and its fractions HDL and LDL and triglycerides). The carotid IMT was measured by B-mode ultrasound in the common carotid artery. RESULTS: Patients in the highest fibrinogen tertile had a significantly higher BMI (p < 0.01), LDL-cholesterol (p < 0.01), leukocyte count, CRP and vWF (p < 0.001). In the univariate model a strong positive relationship was found between plasma fibrinogen and carotid IMT (p < 0.01). Fibrinogen also correlated positively with age, BMI, arterial systolic pressure, cholesterol, cholesterol-LDL, smoking, CRP and vWF (p < 0.01). In the multivariate analysis, the association of fibrinogen with carotid IMT remained significant (p < 0.01) after adjustment for all the parameters analyzed. CONCLUSION: In a population sample of adults without clinically overt atherosclerotic disease, elevated fibrinogen was related to carotid IMT independent of a wide range of important confounding variables
Permanent link: http://hdl.handle.net/10171/21898
Appears in Collections:DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista
DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista

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