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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Cardiopatía hipertensiva > DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista >

Involvement of cardiomyocyte survival-apoptosis balance in hypertensive cardiac remodeling
Authors: Fortuño, M.A. (María Antonia)
Lopez, N. (Natalia)
Gonzalez, A. (Arantxa)
Diez, J. (Javier)
Keywords: Apoptosis/physiology
Cardiomegaly/physiopathology
Hypertension/physiopathology
Myocytes, Cardiac/pathology
Ventricular Remodeling/physiology
Issue Date: 2003
Publisher: Expert Reviews
Publisher version: http://bit.ly/IwRIbw
ISSN: 1744-8344
Citation: Fortuno MA, Lopez N, Gonzalez A, Diez J. Involvement of cardiomyocyte survival-apoptosis balance in hypertensive cardiac remodeling. Expert Rev Cardiovasc Ther 2003 Jul;1(2):293-307.
Abstract
The balance between cell death and cell survival is a tightly controlled process, especially in terminally differentiated cells, such as the cardiomyocyte. Accumulating data support a role for cardiomyocyte apoptosis in the development of several cardiac diseases, including the transition from hypertensive compensatory hypertrophy to heart failure. This review briefly summarizes the status of the knowledge regarding the death-survival balance of cardiomyocytes in the context of hypertensive heart disease. Several molecular and cellular aspects as well as the most relevant pathophysiological implications are presented. Moreover, diagnosis tools under development and the possibilities for pharmacological intervention are also examined.
Permanent link: http://hdl.handle.net/10171/21899
Appears in Collections:DA - CIMA - Servicios de apoyo - Biobanco - Artículos de revista
DA - CIMA - Cardiovasculares - Cardiopatía hipertensiva - Artículos de Revista

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