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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Trombosis y hemostasia > DA - CIMA - Cardiovasculares - Trombosis y Hemostasia - Artículos de Revista >

Prevention of renal fibrin deposition in endotoxin-induced DIC through inhibition of PAI-1
Authors: Montes, R. (Ramón)
Declerck, P.J. (Paul J.)
Calvo, A. (Alfonso)
Montes, M. (Marta)
Hermida, J. (José)
Muñoz, M.C. (María C.)
Rocha, E. (Eduardo)
Keywords: PAI-1
Sepsis
Endotoxemia
Monoclonal antibodies
Kidney
Issue Date: 2000
Publisher: Schattauer
Publisher version: http://bit.ly/LenEy0
ISSN: 0340-6245
Citation: Montes R, Declerck PJ, Calvo A, Montes M, Hermida J, Munoz MC, et al. Prevention of renal fibrin deposition in endotoxin-induced DIC through inhibition of PAI-1. Thromb Haemost 2000 Jul;84(1):65-70.
Abstract
Plasminogen activator inhibitor-1 (PAI-1) increases in endotoxemia thus possibly cooperating in altering the hemostatic balance in a prothrombotic direction. The effect of the inhibition of PAI-1 with the monoclonal antibody MA-33B8 was studied systemically and in kidneys in a lapine model of endotoxin-induced disseminated intravascular coagulation (DIC). The increase in plasmatic PAI activity in the control group (n = 9) was inhibited in the MA-33B8 treated rabbits (n = 5). Control rabbits showed renal fibrin deposits, whereas only one of the MA-33B8 rabbits did so. These results were confirmed immunohistochemically in kidneys as PAI-1 immunostaining was seen inside the glomeruli and larger vessels in the control group, whereas MA-33B8 rabbits showed a remarkable decrease, demonstrating that MA-33B8 successfully inhibited PAI-1 in the kidneys as well. Therefore evidence for the important role of PAI-1 in fibrin generation in endotoxin-induced DIC is presented, suggesting that strategies aiming at its reduction can be useful in this pathology.
Permanent link: http://hdl.handle.net/10171/22121
Appears in Collections:DA - CIMA - Oncología - Nuevas dianas terapéuticas - Artículos de revista
DA - CIMA - Cardiovasculares - Trombosis y Hemostasia - Artículos de Revista

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