Dadun/></a>
				</td>
				<td class= Dadun
   (New user)
Help  | Contact  |  Castellano English  
 

Dadun > Depósito Académico > Clínica Universidad de Navarra > Farmacología clínica > DA - CUN - Farmacología clínica - Artículos de revista >

Anfotericina B forma liposómica: un perfil farmacocinético exclusivo. Una historia inacabada.
Authors: Azanza-Perea, J.R. (José Ramón)
Barberan, J. (Jose)
Keywords: Liposomal amphotericin B
Pharmacokinetic
Invasive fungal infection
Issue Date: 2012
Publisher: Sociedad Espanola de Quimioterapia
Publisher version: http://seq.es/seq/0214-3429/25/1/azanza.pdf
ISSN: 0214-3429
Citation: Perea JR, Barberan J. Anfotericina B forma liposómica: un perfil farmacocinético exclusivo. Una historia inacabada. Rev Esp Quimioter 2012 Mar;25(1):17-24
Abstract
Amphotericin B in its lipid formulation continues to be the reference drug in the treatment of systemic fungal infections despite the time elapse since the development of this compound. The absence of fungal resistance, pharmacokinetics, and the better tolerability profile as compared with the remaining formulations of amphotericin B are sufficient reasons to justify its prominent therapeutic role. The liposome containing liposomal amphotericin B is very stable in relation to the presence of cholesterol and phospholipids are not thermolabile, so that free amphotericin B is almost inexistent (<1%), which explains the reduced incidence of effects related to the drug administration, and a reduction in the incidence of nephrotoxicity (half than that with amphotericin B lipid complex) and that even in some studies at doses of 1 mg/kg has been shown to be negligible. This profile explains the very high plasma drug concentrations and the reduced distribution volume and clearance, with a very prolonged elimination half-life. There are evidences showing that the liposome through amphotericin B is capable of binding to ergosterol present in the fungal membrane and only at this moment would be the antifungal released to exert its pharmacological effects.
Permanent link: http://hdl.handle.net/10171/22324
Appears in Collections:DA - Farmacia - Farmacología - Artículos de revista
DA - CUN - Farmacología clínica - Artículos de revista

Files in This Item:
File:  Rev Esp Quimioter 2012. 17.pdf
Description: 
Size:  470,64 kB
Format:  Adobe PDF
 View / Open 

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.