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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Aterosclerosis e inflamación > DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista >

Clotting activation and impairment of fibrinolysis in malignancy
Authors: Rocha, E. (Eduardo)
Paramo, J.A. (José Antonio)
Fernandez, F.J. (Francisco J.)
Cuesta, B. (Braulia)
Hernandez, M. (M.)
Paloma, M.J. (María José)
Rifon, J. (José)
Keywords: Malignancy
Thrombosis
Clotting activation
Fibrinolysis
Issue Date: 1989
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/0049384889901345
ISSN: 1879-2472
Citation: Rocha E, Paramo JA, Fernandez FJ, Cuesta B, Hernandez M, Paloma MJ, et al. Clotting activation and impairment of fibrinolysis in malignancy. Thromb Res 1989 Jun 15;54(6):699-707.
Abstract
Different coagulation and fibrinolysis parameters were investigated in 149 patients with metastatic and non-metastatic tumours and results were compared with those obtained in a healthy population. Results showed a significant increase of thrombin-antithrombin complexes, fibrinopeptide A (FPA) and fibrin monomers in the group of patients (p less than 0.001). There was also a significant prolongation of euglobulin lysis time (p less than 0.005) and an increase of plasminogen activator inhibitor activity (p less than 0.0001), fibrinogen degradation products (p less than 0.001), and D-dimer (p less than 0.05) in the group of patients as compared to controls; FPA levels were also increased in patients with metastases (p less than 0.005). This study demonstrates clotting activation, at the level of fibrinogen to fibrin conversion, and impairment of fibrinolysis in patients with malignancy.
Permanent link: http://hdl.handle.net/10171/22345
Appears in Collections:DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista

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