Dadun Dadun cabecera universidad cabecera biblioteca
   (New user)
Help  | Contact  |  Castellano English  
 

Dadun > Depósito Académico > Clínica Universidad de Navarra > Cardiología > DA - CUN - Cardiología - Artículos de revista >

Aquaglyceroporins serve as metabolic gateways in adiposity and insulin resistance control
Authors: Rodriguez, A. (Amaia)
Catalan, V. (Victoria)
Gomez-Ambrosi, J. (Javier)
Frühbeck, G. (Gema)
Keywords: Glycerol
Aquaporin
Glucose homeostasis
ATP production
Issue Date: 2011
Publisher: Landes Bioscience
Publisher version: http://www.landesbioscience.com/journals/cc/RodriguezCC10-10.pdf
ISSN: 1538-4101
Citation: Rodriguez A, Catalan V, Gomez-Ambrosi J, Frühbeck G. Aquaglyceroporins serve as metabolic gateways in adiposity and insulin resistance control. Cell Cycle 2011 May 15;10(10):1548-1556.
Abstract
Aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) encompass a subfamily of aquaporins that allow the movement of water and other small solutes, especially glycerol, through cell membranes. Adipose tissue constitutes a major source of glycerol via AQP7. We have recently reported that, in addition to the well-known expression of AQP7 in adipose tissue, AQP3 and AQP9 are also expressed in omental and subcutaneous fat depots. Moreover, insulin and leptin act as regulators of aquaglyceroporins through the PI3K/Akt/mTOR pathway. AQP3 and AQP7 appear to facilitate glycerol efflux from adipose tissue while reducing the glycerol influx into hepatocytes via AQP9 to prevent the excessive lipid accumulation and the subsequent aggravation of hyperglycemia in human obesity. This Extra View focuses on the control of glycerol release by aquaglyceroporins in the adipose tissue and briefly discusses the importance of glycerol as a substrate for hepatic gluconeogenesis, pancreatic insulin secretion and cardiac ATP production.
Permanent link: http://hdl.handle.net/10171/22413
Appears in Collections:DA - Medicina - Endocrinología - Artículos de revista
DA - CUN - Endocrinología y Nutrición - Artículos de revista
DA - CIFA - Laboratorio de investigación metabólica - Artículos de Revista
DA - CUN - Cardiología - Artículos de revista

Files in This Item:
File:  Cell Cycle 2011. 1548.pdf
Description: 
Size:  2,36 MB
Format:  Adobe PDF
 View / Open 

Items in Dadun are protected by copyright, with all rights reserved, unless otherwise indicated.