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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Aterosclerosis e inflamación > DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista >

Effect of DDAVP on endotoxin-induced intravascular coagulation in rabbits
Authors: Paloma, M.J. (María José)
Paramo, J.A. (José Antonio)
Rocha, E. (Eduardo)
Keywords: Blood coagulation/drug effects
Deamino arginine vasopressin/therapeutic use
Disseminated intravascular coagulation/drug therapy
Fibrinolysis/drug effects
Issue Date: 1992
Publisher: Schattauer
Publisher version: http://www.ncbi.nlm.nih.gov/pubmed/1440497
ISSN: 0340-6245
Citation: Paloma MJ, Paramo JA, Rocha E. Effect of DDAVP on endotoxin-induced intravascular coagulation in rabbits. Thromb Haemost 1992 Sep 7;68(3):306-309.
Abstract
We have evaluated the effect of 1-Deamino-8D-arginine vasopressin (DDAVP) on an experimental model of intravascular coagulation (DIC) induced in rabbits by injection of 20 micrograms kg-1 h-1 during 6 h of E. coli lipopolysaccharide. DDAVP significantly ameliorated the platelet drop and fibrinogen decrease (p less than 0.01) induced by endotoxin in control animals. A significant reduction in factor XII consumption (p less than 0.01) and a decrease in the generation of endotoxin induced PAI-1 activity in rabbits circulation was also observed (p less than 0.005). Moreover, fibrin deposition in kidneys of rabbits receiving DDAVP was significantly reduced as compared to control animals. Finally, the mortality rate in the control group was significantly higher than in DDAVP-treated rabbits (p less than 0.01). The hemostatic changes induced by DDAVP correlated with lower fibrin deposition and reduction in mortality rates.
Permanent link: http://hdl.handle.net/10171/22530
Appears in Collections:DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista

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