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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Aterosclerosis e inflamación > DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista >

Evan's syndrome, chronic active hepatitis and focal glomerulonephritis in IgA deficiency
Authors: Cuesta, B. (Braulia)
Fernandez, J. (Javier)
Pardo, J. (J.)
Paramo, J.A. (José Antonio)
Gomez, C. (C.)
Rocha, E. (Eduardo)
Keywords: Chronic active hepatitis
Evan´s syndrome
Focal glomerulonephritis
IgA deficiency
Secretory IgA
Issue Date: 1986
Publisher: Karger
Publisher version: http://bit.ly/LwjeXA
ISSN: 1421-9662
Citation: Cuesta B, Fernandez J, Pardo J, Paramo JA, Gomez C, Rocha E. Evan's syndrome, chronic active hepatitis and focal glomerulonephritis in IgA deficiency. Acta Haematol 1986;75(1):1-5.
Abstract
A 10-year-old female with a complete selective IgA deficiency and recurrent autoimmune disease (chronic active hepatitis, focal glomerulonephritis, hemolytic anemia and thrombopenic purpura) is presented. Both serum IgA and saliva secretory IgA were below the detection limit. The small bowel biopsy using a peroxidase-antiperoxidase technique showed absence of plasma cells secreting IgA. Circulating antibodies against mitochondria, microsomal thyroid antigen were detected as well as rheumatoid factor. Circulating immune complexes were present. A positive Coombs' test and a slightly positive reaction for cryoagglutinins were demonstrated. No alterations in cellular immunity were observed. Clinical and analytical improvement with prednisone and azathioprine was obtained.
Permanent link: http://hdl.handle.net/10171/22585
Appears in Collections:DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista

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