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Farmacología de los azoles
Other Titles: Pharmacology of azoles
Authors: Azanza, J.R. (José Ramón)
Garcia-Quetglas, E. (Emilio)
Sadaba, B. (Belén)
Keywords: Pharmacology
Posaconazole
Itraconazole
Issue Date: 2007
Publisher: Elsevier España
Publisher version: http://www.reviberoammicol.com/2007-24/223227.pdf
ISSN: 1130-1406
Citation: Azanza JR, Garcia-Quetglas E, Sadaba B. Farmacología de los azoles. Rev Iberoam Micol 2007 Sep 30;24(3):223-227.
Abstract
Azole antifungals have different pharmacokinetic characteristics: complete oral absorption for Voriconazole, and to a lesser extent for fluconazole. The absorption of posaconazole and itraconazole increases with food intake. All of them have high tissue distribution with low plasma concentrations, especially low in the case of posaconazole and itraconazole. Posaconazole and itraconazole have high plasmatic protein binding and consequently both have a very low free fraction. Elimination of azole antifungals is through a metabolic pathway with CYP450 isoenzymes, and has a non linear pharmacokinetics with a high risk of interation with other drugs since azoles have the ability of CYP450 isoenzymes inhibition. Possibly the parameter that defines more precisely their efficacy is AUIC with an optimum value near 20, although cut-off values must be defined since some azoles may have difficulty to reach this value.
Permanent link: http://hdl.handle.net/10171/22724
Appears in Collections:DA - CUN - Farmacología clínica - Artículos de revista

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