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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Aterosclerosis e inflamación > DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista >

Fibrinogen and fibrin degradation products in patients undergoing open-heart surgery
Authors: Rifon, J. (José)
Fernandez, J. (J.)
Paramo, J.A. (José Antonio)
Cuesta, B. (Braulia)
Rocha, E. (Eduardo)
Keywords: Cardiac surgery
Fibrinogen degradation products
Fibrin degradation products
Fibrinogen
Issue Date: 1990
Publisher: Lippincott, Williams & Wilkins
Publisher version: http://bit.ly/NCPwBX
ISSN: 1473-5733
Citation: Rifon J, Fernandez J, Paramo JA, Cuesta B, Rocha E. Fibrinogen and fibrin degradation products in patients undergoing open-heart surgery. Blood Coagul Fibrinolysis 1990 Oct;1(4-5):509-512.
Abstract
We have determined fibrinogen and fibrin degradation products (FgDP and FbDP respectively) by an ELISA method using specific monoclonal antibodies in 100 patients undergoing cardiopulmonary bypass (CPB) for valvular heart disease and in 60 patients undergoing aorto-coronary bypass surgery. Blood samples were taken pre-operatively and on post-operative days 1 and 5. Post-operative evolution was similar in both patient groups, with a significant increase in FgDP on post-operative days 1 and 5 with respect to baseline value (P less than 0.01). FbDP were also significantly higher on post-operative days 1 and 5 (P less than 0.001), especially the day after surgery in patients with valvular disease as compared with coronary patients (P less than 0.01). Our results indicate that fibrinolysis is more important than fibrinogenolysis after open-heart surgery, which may have pathophysiological implications.
Permanent link: http://hdl.handle.net/10171/22818
Appears in Collections:DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista

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