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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Aterosclerosis e inflamación > DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista >

Estabilización de la placa de ateroma: un nuevo concepto basado en la biología dinámica de la aterosclerosis
Authors: Paramo, J.A. (José Antonio)
Orbe, J. (Josune)
Rodriguez, J.A. (José Antonio)
Keywords: Aterosclerosis
Estabilización de la placa
Técnicas no invasivas de imagen vascular
Estrategias antiateroscleróticas
Issue Date: 2003
Publisher: Elsevier
Publisher version: http://www.elsevier.es/en/linksolver/ft/ivp/0025-7753/121/583
ISSN: 0025-7753
Citation: Paramo JA, Orbe J, Rodriguez JA. Estabilización de la placa de ateroma: un nuevo concepto basado en la biología dinámica de la aterosclerosis. Med Clin (Barc) 2003 Nov 1;121(15):583-587.
Abstract
As it is well-known, a thrombus evolving into a disrupted/eroded atherosclerotic plaque causes most acute coronary syndromes. Plaque stabilization via reduction of the lipid core and/or thickening of the fibrous cap is one of the possible mechanisms accounted for the clinical benefits displayed by different anti-atherosclerotic strategies. The concept of plaque stabilization was developed to explain how lipid-lowering agents could decrease adverse coronary events without substantial modifications of the atherosclerotic lesion. A number of imaging modalities (vascular ultrasound, MRI, and coronary computed tomography) are used for non-invasive assessment of atherosclerosis; most of them can identify luminal stenosis, wall thickness and plaque volume and composition, and can even characterize the rupture-prone vulnerable plaques. Several classes of drugs, including statins, ACE inhibitors, -blockers, and antithrombotics, are able to reduce the plaque burden and the incidence of cardiovascular events; this may be attibutable, at least in part, to plaque-stabilizing effects and the improvement of endothelial dysfunction
Permanent link: http://hdl.handle.net/10171/22851
Appears in Collections:DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista

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