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Dadun > Depósito Académico > Clínica Universidad de Navarra > Ginecología y Obstetricia > DA - CUN - Ginecología y Obstetricia - Artículos de revista >

Neoangiogenesis in early cervical cancer: Correlation between color Doppler findings and risk factors. A prospective observational study
Authors: Jurado, M. (Matías)
Galvan, R. (R.)
Martinez-Monge, R. (Rafael)
Mazaira, J. (Jesús)
Alcazar, J.L. (Juan Luis)
Keywords: Neovascularization, pathologic/ultrasonography
Ultrasonography, Doppler
Uterine cervical neoplasms/blood supply/mortality/therapy/ultrasonography
Issue Date: 2008
Publisher: BioMed Central
Publisher version: http://www.wjso.com/content/pdf/1477-7819-6-126.pdf
ISSN: 1477-7819
Citation: Jurado M, Galvan R, Martinez-Monge R, Mazaira J, Alcazar JL. Neoangiogenesis in early cervical cancer: correlation between color Doppler findings and risk factors. A prospective observational study. World J Surg Oncol 2008 Nov 25;6:126.
Abstract
Background: The aim of the present article was to evaluate whether angiogenic parameters as assessed by transvaginal color Doppler ultrasound (TVCD) may predict those prognostic factors related to recurrence. Methods: A total of 27 patients (mean age: 51.3 years, range: 29 to 85) with histologically proven early stage invasive cervical cancer were evaluated by TVCD prior to surgery. Subjective assessment of the amount of vessels within the tumor (scanty-moderate or abundant) and pulsatility index (PI) were recorded. All patients underwent radical hysterectomy and pelvic lymph node dissection. Postoperative treatment (RT or chemoradiotherapy) was given according to risk factors (positive lymph nodes, parametrial and vaginal margin involvement, depth stromal invasion, lymph-vascular space involvement) Results: Tumors with "abundant" vascularization were significantly associated with pelvic lymph node metastases, depth stromal invasion > 10 mm, lymph-vascular space involvement, tumor diameter > 17.5 mm, and parametrial involvement. Postoperative treatment was significantly more frequent in patients with "abundant" vascularization (OR: 20.8, 95% CIs: 2 to 211). The presence of scanty-moderate vascularization with a PI < 0.82 or abundant vascularization with either PI > 0.82 or PI < 0.82 was associated with high-risk group in 94.4% of the cases (OR: 21.2, 95% CI: 1.9 to 236.0) Conclusion: The results are consistent with a relationship between tumor angiogenesis and prognostic factors for recurrence in early cervical cancer. "Abundant" vascularization and PI < 0.82 may be related to postoperative treatment due to risk factors.
Permanent link: http://hdl.handle.net/10171/22870
Appears in Collections:DA - Medicina - Ginecología y Obstetricia - Artículos de revista
DA - Medicina - Oncología - Artículos de revista
DA - CUN - Oncología radioterápica - Artículos de revista
DA - CUN - Ginecología y Obstetricia - Artículos de revista

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