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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Ciencias Cardiovasculares > Aterosclerosis e inflamación > DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista >

Thrombin activation and increased fibrinolysis in patients with chronic liver disease
Authors: Paramo, J.A. (José Antonio)
Rifon, J. (José)
Fernandez, J. (Javier)
Cuesta, B. (Braulia)
Rocha, E. (Eduardo)
Keywords: Liver disease
Disseminated intravascular coagulation
Thrombin-antithrombin
Tissue-type plasminogen activator
Fibrinogen degradation products
Fibrin degradation products
Issue Date: 1991
Publisher: Lippincott, Williams & Wilkins
Publisher version: http://bit.ly/KEDodE
ISSN: 1473-5733
Citation: Paramo JA, Rifon J, Fernandez J, Cuesta B, Rocha E. Thrombin activation and increased fibrinolysis in patients with chronic liver disease. Blood Coagul Fibrinolysis 1991 Apr;2(2):227-230.
Abstract
The respective roles of intravascular coagulation (DIC) and fibrinolysis were assessed in severe chronic liver disease by measuring thrombin-antithrombin (TAT) complexes, tissue-type plasminogen activator antigen (tPA Ag) and fibrinogen and fibrin degradation products (FgDP and FbDP respectively) in 66 patients with liver disease caused by cirrhosis (n = 34) or chronic hepatitis (n = 32) as compared to findings in a control group (n = 30). There was a significant increase of TAT complexes (P less than 0.01), tPA Ag (P less than 0.002), FDP and FbDP (P less than 0.001) in patients as compared to controls. FbDP increase was more evident in patients with cirrhosis than in those with hepatitis (P less than 0.01). Significant correlations between these parameters with some liver function tests were also demonstrated. Thus, in patients with severe liver disease, an increased thrombin activity, as demonstrated by high TAT levels; followed by hyperfibrinolysis suggest that a low grade DIC may occur.
Permanent link: http://hdl.handle.net/10171/22871
Appears in Collections:DA - Medicina - Hematología - Artículos de revista
DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CIMA - Cardiovasculares - Aterosclerosis e inflamación - Artículos de revista

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