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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Virología > DA - CIMA - Terapia génica y Hepatología - Virología - Artículos de revista >

Detection of hepatitis C virus antibodies with new recombinant antigens: assessment in chronic liver diseases
Authors: Riezu-Boj, J.I. (José Ignacio)
Parker, D. (D.)
Civeira, M.P. (María Pilar)
Phippard, D. (D.)
Corbishley, T.P. (T.P.)
Camps, J. (J.)
Castilla, A. (A.)
Prieto, J. (Jesús)
Keywords: HCV antibody
Polymerase chain reaction
Chronic hepatitis C
Chronic hepatitis B
Alcoholic !iver disease
Primary biliary cirrhosis
Hepatocellular carcinoma
Issue Date: 1992
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/016882789290061S
ISSN: 1600-0641
Citation: Riezu-Boj JI, Parker D, Civeira MP, Phippard D, Corbishley TP, Camps J, et al. Detection of hepatitis C virus antibodies with new recombinant antigens: assessment in chronic liver diseases. J Hepatol 1992 Jul;15(3):309-313.
Abstract
A new serological assay to detect antibodies against hepatitis C, based on a recombinant protein (BHC10) which incorporates structural and non-structural viral antigens, was tested in 67 healthy subjects and 409 patients with various forms of liver disease. Results were compared with the current assay based on the recombinant non-structural viral antigen c100 and with the recently introduced second-generation assay, Ortho2. None of the healthy subjects was positive by any of the assays. In patients with chronic non-A, non-B hepatitis the prevalence of anti-BHC10 was 96.8%, higher than anti-c100 (83.3%, p less than 0.001) and similar to Ortho2 (94.3%). False-positive results were less frequently found when BHC10 was used. These findings show that assays incorporating structural and non-structural antigens provide higher sensitivity to detect hepatitis C virus infection and they define an almost exclusive role of hepatitis C virus in the genesis of chronic non-A, non-B hepatitis.
Permanent link: http://hdl.handle.net/10171/23015
Appears in Collections:DA - Medicina - Medicina Interna - Artículos de revista
DA - CUN - Medicina interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Virología - Artículos de revista

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