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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Virología > DA - CIMA - Terapia génica y Hepatología - Virología - Artículos de revista >

Hepatitis B and C viral infections in patients with hepatocellular carcinoma
Authors: Ruiz, J. (Juan)
Sangro, B. (Bruno)
Cuende, J.I. (J.I.)
Beloqui, O. (Óscar)
Riezu-Boj, J.I. (José Ignacio)
Herrero, J.I. (José Ignacio)
Prieto, J. (Jesús)
Keywords: Carcinoma, hepatocellular/immunology
Hepacivirus/isolation and purification
Hepatitis B/immunology
Hepatitis B virus/isolation and purification
Hepatitis C/immunology
Liver neoplasms/immunology
Issue Date: 1992
Publisher: Wiley-Blackwell
Publisher version: http://onlinelibrary.wiley.com/doi/10.1002/hep.v16:3/issuetoc
ISSN: 1527-3350
Citation: Ruiz J, Sangro B, Cuende JI, Beloqui O, Riezu-Boj JI, Herrero JI, et al. Hepatitis B and C viral infections in patients with hepatocellular carcinoma. Hepatology 1992 Sep;16(3):637-641.
Abstract
The prevalence of hepatitis B and C virus infections was studied in 70 patients diagnosed as having hepatocellular carcinoma. In addition to viral serological markers, serum hepatitis B virus DNA and hepatitis C virus RNA were determined with a nested polymerase chain reaction assay. Twelve patients (17%) were HBsAg positive, 26 (37%) had antibodies to HBs, HBc or both and 32 (46%) were negative for all hepatitis B virus serological markers. Prevalence of the antibody to hepatitis C virus was 63% (44 patients). Hepatitis B virus DNA was detected in 24 of the 66 tested patients (36%). Twelve of these hepatitis B virus DNA-positive patients were HBsAg negative (seven were positive for antibody to HBs, antibody to HBc or both and five were negative for all hepatitis B virus serological markers). Hepatitis C virus RNA was found in 42 of 68 patients (62%). A high correlation (95%) existed between hepatitis C virus RNA and hepatitis C virus antibodies. Nevertheless, two patients without antibody to hepatitis C virus had serum hepatitis C virus RNA sequences. Coinfection by the two viruses was detected in nine subjects (14%), but no clinical differences were found between these and the rest of the patients. We conclude that nearly 90% (62 of the 70 patients studied) of cases of hepatocellular carcinoma in our geographical area are related to hepatitis virus infections (detected by serological or molecular studies). Hepatitis C is more prevalent than hepatitis B virus in patients with hepatocellular carcinoma, and the infection is still active when the tumor is diagnosed.
Permanent link: http://hdl.handle.net/10171/23044
Appears in Collections:DA - Medicina - Medicina Interna - Artículos de revista
DA - CUN - Medicina interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Virología - Artículos de revista

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